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Showing 1–3 of 3 results
Advanced filters: Author: Pierre Fontanaud Clear advanced filters
  • Experience-dependent plasticity and functional adaptation are thought to be restricted to the central nervous and immune systems. This study shows that long-lasting experience-dependent plasticity is a key feature of endocrine cell networks, allowing improved tissue function and hormone output following repeat demand.

    • David J. Hodson
    • Marie Schaeffer
    • Patrice Mollard
    ResearchOpen Access
    Nature Communications
    Volume: 3, P: 1-10
  • Mice lacking the metabotropic glutamate receptor mGluR7 are hypersensitive to convulsant drugs. But how does mGluR7 act to prevent seizures? Here the authors show that interfering with the interaction between mGluR7 and the intracellular adaptor protein PICK1 causes a phenotype in mice and rats that is reminiscent of human absence epilepsy.

    • Federica Bertaso
    • Chuansheng Zhang
    • Mireille Lerner-Natoli
    Research
    Nature Neuroscience
    Volume: 11, P: 940-948