Mice lacking the metabotropic glutamate receptor mGluR7 are hypersensitive to convulsant drugs. But how does mGluR7 act to prevent seizures? Here the authors show that interfering with the interaction between mGluR7 and the intracellular adaptor protein PICK1 causes a phenotype in mice and rats that is reminiscent of human absence epilepsy.
- Federica Bertaso
- Chuansheng Zhang
- Mireille Lerner-Natoli