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Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection

Pierre Guermonprez and colleagues have worked out how a subset of dendritic cells expands in individuals with severe malaria. Plasmodium infection causes an accumulation of xanthine in infected red blood cells. The researchers found that type I interferon triggers an increase in the enzyme that metabolizes xanthine to uric acid. Uric acid then acts on mast cells to release Flt3 ligand, an important regulator of dendritic cells, which in turn stimulate T cells to respond to the infection.

Pierre Guermonprez
Julie Helft
Michel C Nussenzweig
Research19 May 2013
Nature Medicine

Volume: 19, P: 730-738
Engineered niches support the development of human dendritic cells in humanized mice

Classical human dendritic cells (cDCs) are rare sentinel cells specialized in regulating adaptive immunity. Here, the authors show that expression of membrane bound FLT3L, along with stem cell factor (SCF) and CXCL12 in stromal cells induces specification of pre/AS-DCs, type 1 and type2 cDC from haematopoietic stem cells.

Giorgio Anselmi
Kristine Vaivode
Pierre Guermonprez
ResearchOpen Access28 Apr 2020
Nature Communications

Volume: 11, P: 1-18
Dendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors

Response to immune checkpoint inhibitors (ICIs) in patients with non-small cell lung cancer (NSCLC) remains suboptimal, even for tumors with elevated tumor mutational burden. Here the authors generate a model of NSCLC with enhanced mutational load, showing that, while still resistant to ICIs, hypermutated tumors become sensitive to dendritic cell-targeted therapy.

Lucía López
Luciano Gastón Morosi
Federica Benvenuti
ResearchOpen Access13 Mar 2024
Nature Communications

Volume: 15, P: 1-17
TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses

Acquisition of dying tumor cell-associated antigens is an essential step for the initiation of anti-tumor immune response by conventional type 1 dendritic cells (cDC1). Here the authors show that the loss of TIM4 expression in lung tumor associated cDC1 is associated with less efficient uptake of cell associated antigens and reduction of CD8 + T cell activation in advanced lung tumors.

Nicoletta Caronni
Giulia Maria Piperno
Federica Benvenuti
ResearchOpen Access14 Apr 2021
Nature Communications

Volume: 12, P: 1-15
ER–phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells

Pierre Guermonprez
Loredana Saveanu
Sebastian Amigorena
Research25 Sept 2003
Nature

Volume: 425, P: 397-402
Inflammasome activation: a monocyte lineage privilege

Inflammasomes have been reported to function in a wide variety of innate immune cells; however, their activity now seems to be more restricted than previously thought.

Pierre Guermonprez
Julie Helft
News & Views11 Mar 2019
Nature Immunology

Volume: 20, P: 383-385
IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses

T cell receptors (TCR) are internalized when activated by their ligands. Here the authors show that the internalized TCRs are localized to endosomes expressing IRAP and Syntaxin 6 to maintain intracellular signalling capacity, whose importance is shown by the absence of efficient polyclonal anti-tumour response in mice with T-specific conditional deletion of IRAP.

Irini Evnouchidou
Pascal Chappert
Loredana Saveanu
ResearchOpen Access02 Jun 2020
Nature Communications

Volume: 11, P: 1-16
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues

Claudia Waskow
Kang Liu
Michel Nussenzweig
Research11 May 2008
Nature Immunology

Volume: 9, P: 676-683
Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection

Cytokines and their associated pathways can affect survival ofMycobacterium tuberculosis in macrophages, representing potential targets for host-directed therapies. Here, Péan et al. show that cytokine-STAT signalling promotes mycobacterial survival within macrophages by deregulating lipid droplet homeostasis.

Claire B. Péan
Mark Schiebler
Marc S. Dionne
ResearchOpen Access06 Mar 2017
Nature Communications

Volume: 8, P: 1-11
Breast cancer remotely imposes a myeloid bias on haematopoietic stem cells by reprogramming the bone marrow niche

Gerber-Ferder et al. show that non-metastatic breast tumours remotely reprogram the bone marrow stroma and instruct the myeloid differentiation of long-term haematopoietic stem cells.

Yohan Gerber-Ferder
Jason Cosgrove
Julie Helft
Research30 Nov 2023
Nature Cell Biology

Volume: 25, P: 1736-1745
The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens

Fiona Clarke
Harriet A. Purvis
Andrew P. Cope
ResearchOpen Access23 Aug 2018
Scientific Reports

Volume: 8, P: 1-11

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Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection

Engineered niches support the development of human dendritic cells in humanized mice

Dendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors

TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses

ER–phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells

Inflammasome activation: a monocyte lineage privilege

IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues

Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection

Breast cancer remotely imposes a myeloid bias on haematopoietic stem cells by reprogramming the bone marrow niche

The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens

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