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Showing 1–3 of 3 results
Advanced filters: Author: Pierre-Alain Burnouf Clear advanced filters

  • Retention of drugs loaded into liposomes is a major challenge to effective targeted drug delivery. Here, the authors report on the modification of drugs with a glycosidic pH sensitive switch to improve encapsulation and retention of drugs and demonstrate application in an in vivo cancer model.

    • Pierre-Alain Burnouf
    • Yu-Lin Leu
    • Steve R. Roffler
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • The majority of treatment options for cancers are ineffective due to limited therapeutic targeting. Here, the authors develop bispecific antibodies that effectively target nanomaterials to triple-negative breast cancer cell receptors and deliver therapeutics leading to inhibition of tumour growth.

    • Yu-Cheng Su
    • Pierre-Alain Burnouf
    • Steve R. Roffler
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Hsien-Ya Lin, Chia-Yu Chen, Ting-Chien Lin and colleagues perform structure-guided modifications of the compound uronic isofagomaine in order to engineer a highly specific and potent inhibitor of gut bacterial β-glucuronidases (GUSs). The authors present eight crystal structures and demonstrate in vivo efficacy of the optimised C6-alkyl derivative inhibitor in mice models. This study may enhance the development of inhibitors of microbial GUS for use in colorectal cancer therapy to minimize the undesired side effects of irinotecan treatment.

    • Hsien-Ya Lin
    • Chia-Yu Chen
    • Chun-Hung Lin
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-10