The molecular regulation of endothelial cells (ECs) in metastasis remains unclear. Here, the authors use single-cell RNA-seq to examine the reprogramming of lung ECs in mouse models of melanoma metastasis, revealing that PIM3 protects capillary integrity and that its inhibition increases vascular leakage and metastatic colonisation.
- Niina M. Santio
- Keerthana Ganesh
- Pipsa Saharinen
