The combined effect of cytotoxic T-lymphocyte antigen-4-Ig (CTLA4Ig) and interleukin-1 receptor antagonist (IL1ra) on the survival of subcutaneous mouse islet grafts with temperature-sensitive hydrogel, pNIPAAm-chitosan-hyaluronic acid (CPNHA), and gelatin microspheres in an allogeneic mouse model is examined. The survival of the allogeneic islets was prolonged when the grafts were transplanted into a subcutaneous matrix composed of CPN-CTLA4Ig-HA (CPNCHA) and gelatin microspheres containing IL1ra relative to those implanted in CPNHA containing gelatin microspheres without an immunomodulator.
- Hau-Yuan Hou
- Shin-Huei Fu
- Brend Ray-Sea Hsu
