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STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor

Here the authors show how the DNA-sensing cGAS–STING pathway activates NF-κB and inflammatory gene expression with delayed kinetics via post-Golgi endolysosomal signaling.

Bao-cun Zhang
Alice Pedersen
Søren R. Paludan
Research19 Sept 2025
Nature Immunology

P: 1-15
Structure and function of the Zika virus full-length NS5 protein

Zika virus infection can cause human birth defects and Guillain-Barré syndrome. Here the authors present the structures of the full-length nonstructural protein 5 and its RNA-dependent RNA polymerase domain of Zika virus, which are targets for inhibitors of virus replication.

Baoyu Zhao
Guanghui Yi
Pingwei Li
ResearchOpen Access27 Mar 2017
Nature Communications

Volume: 8, P: 1-9
The molecular basis of tight nuclear tethering and inactivation of cGAS

Structural studies show that cyclic GMP–AMP synthase binds to nucleosomes through its DNA-binding site, which maintains it in an inactive conformation and prevents self-DNA binding.

Baoyu Zhao
Pengbiao Xu
Pingwei Li
Research10 Sept 2020
Nature

Volume: 587, P: 673-677
Energy landscape reshaped by strain-specific mutations underlies epistasis in NS1 evolution of influenza A virus

Influenza A virus (IAV) nonstructural protein 1 (NS1) is a multifunctional virulence factor that interacts with several host factors such as phosphatidylinositol-3-kinase (PI3K). NS1 binds specifically to the p85β regulatory subunit of PI3K and subsequently activates PI3K signaling. Here, Kim et al. show that functionally near-neutral, strain-specific NS1 mutations lead to variations in binding kinetics to p85β exhibit long-range epistatic interactions. Applying NMR they provide evidence that the structural dynamics of the NS1 hydrophobic core have evolved over time and contributed to epistasis.

Iktae Kim
Alyssa Dubrow
Jae-Hyun Cho
ResearchOpen Access01 Oct 2022
Nature Communications

Volume: 13, P: 1-13
A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1

A molecular model of STING-mediated signalling is proposed, as structural analysis identifies a crucial motif for the binding of TBK1 to STING, and a separate model involved in IRF-3 binding.

Baoyu Zhao
Fenglei Du
Pingwei Li
Research22 May 2019
Nature

Volume: 569, P: 718-722
The deubiquitinase Otub1 controls the activation of CD8⁺ T cells and NK cells by regulating IL-15-mediated priming

IL-15 has important functions in the activation and homeostasis of cytotoxic T lymphocytes (CTLs) and NK cells. Sun and colleagues demonstrate that the deubiquitinase Otub1 controls CTLs and NK cells in a cell-intrinsic manner by negatively regulating IL-15 signaling.

Xiaofei Zhou
Jiayi Yu
Shao-Cong Sun
Research10 Jun 2019
Nature Immunology

Volume: 20, P: 879-889
SWI2/SNF2 ATPase CHR2 remodels pri-miRNAs via Serrate to impede miRNA production

The chromatin remodelling protein CHR2 interacts with Serrate in Arabidopsis to regulate microRNA biogenesis.

Zhiye Wang
Zeyang Ma
Xiuren Zhang
Research16 May 2018
Nature

Volume: 557, P: 516-521
The malectin-like receptor-like kinase LETUM1 modulates NLR protein SUMM2 activation via MEKK2 scaffolding

Plants with loss of function mutations in the MEKK1–MKK1/2–MPK4 MAP kinase pathway show strong autoimmunity phenotypes and dwarfism. Through a suppressor genetic screen, the malectin-like receptor kinase LET1 is identified as a new regulator of immune signalling.

Jun Liu
Yanyan Huang
Ping He
Research24 Aug 2020
Nature Plants

Volume: 6, P: 1106-1115
Circulating and tumor-infiltrating mucosal associated invariant T (MAIT) cells in colorectal cancer patients

Limian Ling
Yuyang Lin
Yanfang Jiang
ResearchOpen Access03 Feb 2016
Scientific Reports

Volume: 6, P: 1-10

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