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Showing 1–2 of 2 results
Advanced filters: Author: Piotr Bragoszewski Clear advanced filters

  • The mitochondrial TIM23-complex facilitates anterograde precursor transport across the inner membrane into the matrix and lateral release of precursors into the membrane. Here authors show that the import motor J-protein Pam18 controls lateral protein release into the lipid bilayer.

    • Alexander Benjamin Schendzielorz
    • Piotr Bragoszewski
    • Peter Rehling
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Mitochondrial dysfunction and cellular protein homeostasis failure are hallmarks of many diseases and age-associated pathologies; this study shows that the mitochondrial import defect of nuclear-encoded proteins triggers a cellular pathway, termed unfolded protein response activated by mistargeting of proteins (UPRam), that acts to minimize the stress caused by non-imported mitochondrial precursor proteins in order to sustain cellular protein homeostasis and organismal fitness.

    • Lidia Wrobel
    • Ulrike Topf
    • Agnieszka Chacinska
    Research
    Nature
    Volume: 524, P: 485-488