Nature Search

Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms

Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis involving evasion of immune control. Here, the authors perform a comprehensive analysis of single-cell multi-omic data revealing either a myeloid-enriched or adaptive-enriched tumour microenvironment, linked to distinct B and T cell clonal selection and differentiation, distinct overall survival, and potential therapeutic approaches.

Shivan Sivakumar
Ashwin Jainarayanan
Rachael Bashford-Rogers
ResearchOpen Access06 Feb 2025
Nature Communications

Volume: 16, P: 1-20
CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade

Analysis of multiple cohorts of patients with melanoma demonstrates a positive association between cytomegalovirus serostatus and overall survival in patients treated with monotherapy but not combination immune checkpoint blockade, as well as delayed onset of immune-related adverse events across both treatment types, as well as delayed development of metastatic disease in seropositive patients.

Gusztav Milotay
Martin Little
Benjamin P. Fairfax
ResearchOpen Access23 Apr 2025
Nature Medicine

Volume: 31, P: 2350-2364
Comparative metagenomic analysis of the oral microbiome in COVID-19 patients and healthy individuals

Piyush Bhanu
Sakshi Buchke
Jitendra Kumar
ResearchOpen Access25 Mar 2025
Scientific Reports

Volume: 15, P: 1-16
High accuracy indoor positioning system using Galois field-based cryptography and hybrid deep learning

Mohammad Mazyad Hazzazi
Prashant Kumar Shukla
Mohd Asif Shah
ResearchOpen Access29 Apr 2025
Scientific Reports

Volume: 15, P: 1-23
YBa₂Cu₃O₇ as a high-temperature superinductor

Pearl inductance in thin films of YBCO enables terahertz superinductance and achieves impedance surpassing the quantum resistance limit, promising advancements in quantum and photonic technologies.

Yogesh Kumar Srivastava
Teng Chen Ietro Pang
Ranjan Singh
Research05 Feb 2025
Nature Materials

Volume: 24, P: 883-890
Instagram fake profile detection using an ensemble learning method

Bharti Goyal
Nasib Singh Gill
Shreyas J
ResearchOpen Access21 Jul 2025
Scientific Reports

Volume: 15, P: 1-17
IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma

Genetic analyses in a cohort of patients with melanoma receiving immunotherapy reveal that variants in IL7 are associated with immune-related adverse events and highlight the role of B cells in mediating toxicity.

Chelsea A. Taylor
Robert A. Watson
Benjamin P. Fairfax
ResearchOpen Access16 Dec 2022
Nature Medicine

Volume: 28, P: 2592-2600
An African vulture optimization algorithm based energy efficient clustering scheme in wireless sensor networks

Mohit Kumar
Ashwani Kumar
Shitharth Selvarajan
ResearchOpen Access28 Dec 2024
Scientific Reports

Volume: 14, P: 1-18
In vivo tumor immune microenvironment phenotypes correlate with inflammation and vasculature to predict immunotherapy response

Standard assessment of immune infiltration of biopsies is not sufficient to accurately predict response to immunotherapy. Here, the authors show that reflectance confocal microscopy can be used to quantify dynamic vasculature and inflammatory features to better predict treatment response in skin cancers.

Aditi Sahu
Kivanc Kose
Milind Rajadhyaksha
ResearchOpen Access09 Sept 2022
Nature Communications

Volume: 13, P: 1-19
Local immune response to food antigens drives meal-induced abdominal pain

In mice, oral tolerance to food antigens can break down after enteric infection, and this leads to food-induced pain resembling irritable bowel syndrome in humans.

Javier Aguilera-Lizarraga
Morgane V. Florens
Guy E. Boeckxstaens
Research13 Jan 2021
Nature

Volume: 590, P: 151-156
Evaluating the detectability of methane point sources from satellite observing systems using microscale modeling

Piyush Bhardwaj
Rajesh Kumar
Branko Kosovic
ResearchOpen Access19 Oct 2022
Scientific Reports

Volume: 12, P: 1-9
Molecular dynamics simulation and docking studies reveals inhibition of NF-kB signaling as a promising therapeutic drug target for reduction in cytokines storms

Abhishek Kumar
Tharun Bharadwaj
Vachaspati Mishra
ResearchOpen Access30 Apr 2025
Scientific Reports

Volume: 15, P: 1-13
An immunodominant NP_105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease

Peng et al. find that immunodominant cytotoxic T lymphocytes (CTLs) specific for NP_105–113-B*07:02 are associated with reduced COVID-19 severity. Mechanistically, NP_105–113-B*07:02-specific CTLs show potent antiviral functionality and may represent rational T cell vaccine targets.

Yanchun Peng
Suet Ling Felce
Tao Dong
ResearchOpen Access01 Dec 2021
Nature Immunology

Volume: 23, P: 50-61
Vaccination to prevent T cell subversion can protect against persistent hepacivirus infection

Development of a HCV vaccine is hampered by a lack of appropriate small animal models. Here, Hartlage et al. describe a rat model of hepacivirus persistence and show that persistence can be prevented by vaccination with viral non-structural proteins.

Alex S. Hartlage
Satyapramod Murthy
Amit Kapoor
ResearchOpen Access07 Mar 2019
Nature Communications

Volume: 10, P: 1-11
Assessment of antibacterial, nematicidal and herbicidal activities of Cautleya spicata (Sm.) Baker extracts, with chemical profiling using GC-MS

Sonu Kumar Mahawer
Himani Karakoti
Yonglin Ren
ResearchOpen Access28 Feb 2025
Scientific Reports

Volume: 15, P: 1-21
CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production

Antibody responses are regulated by selective survival of B cells with proper antigen specificity. Here the authors show that CEACAM1 is critical for B-cell survival during homeostasis and antiviral responses.

Vishal Khairnar
Vikas Duhan
Karl S. Lang
ResearchOpen Access18 Feb 2015
Nature Communications

Volume: 6, P: 1-13
PEPlife: A Repository of the Half-life of Peptides

Deepika Mathur
Satya Prakash
Gajendra P. S. Raghava
ResearchOpen Access07 Nov 2016
Scientific Reports

Volume: 6, P: 1-7
The role of generative AI tools in shaping mechanical engineering education from an undergraduate perspective

Harshal Akolekar
Piyush Jhamnani
Dhruv Kumar
ResearchOpen Access17 Mar 2025
Scientific Reports

Volume: 15, P: 1-14
Advances to IoT security using a GRU-CNN deep learning model trained on SUCMO algorithm

Amit Sagu
Nasib Singh Gill
Mohd Asif Shah
ResearchOpen Access12 May 2025
Scientific Reports

Volume: 15, P: 1-16
Physicochemical and biological analysis of river Yamuna at Palla station from 2009 to 2019

Pankaj Joshi
Akshansha Chauhan
Yuei-An Liou
ResearchOpen Access21 Feb 2022
Scientific Reports

Volume: 12, P: 1-19
Spectroscopic insight into breast cancer: profiling small extracellular vesicles lipids via infrared spectroscopy for diagnostic precision

Abhay Mishra
Sadaqa Zehra
Saroj Kumar
ResearchOpen Access23 Apr 2024
Scientific Reports

Volume: 14, P: 1-10
Applying YOLOv6 as an ensemble federated learning framework to classify breast cancer pathology images

Chhaya Gupta
Nasib Singh Gill
Piyush Kumar Shukla
ResearchOpen Access30 Jan 2025
Scientific Reports

Volume: 15, P: 1-35
ChaQra: a cellular unit of the Indian quantum network

Shashank Gupta
Iteash Agarwal
Dilip Singh
ResearchOpen Access20 Jul 2024
Scientific Reports

Volume: 14, P: 1-13
Understanding non-stationarity of hydroclimatic extremes and resilience in Peninsular catchments, India

Nikhil Kumar
Piyush Patel
Manish Kumar Goyal
ResearchOpen Access02 Aug 2023
Scientific Reports

Volume: 13, P: 1-13
Geospatial data for peer-to-peer communication among autonomous vehicles using optimized machine learning algorithm

T. M. Aruna
Piyush Kumar
Arunkumar Yadav
ResearchOpen Access30 Aug 2024
Scientific Reports

Volume: 14, P: 1-13
Towards in vitro models for reducing or replacing the use of animals in drug testing

Pharmaceutical companies continue to advocate for the use of in vitro models towards the reduction of animal use in drug discovery and development while acknowledging that further advancements are needed to heighten the models’ current state of readiness.

David M. Stresser
Anna K. Kopec
Kimberly A. Homan
Comments & Opinion27 Dec 2023
Nature Biomedical Engineering

Volume: 8, P: 930-935
Comment on: ‘Prevalence of co-existent neoplasia in clinically diagnosed pterygia in a UK population’

Suraj Kumar Chaurasiya
Mahendra Singh
Piyush Kohli
Comments & Opinion10 Feb 2024
Eye

Volume: 38, P: 1610-1611
Method and its Composition for encapsulation, stabilization, and delivery of siRNA in Anionic polymeric nanoplex: An In vitro- In vivo Assessment

Nidhi Raval
Hardi Jogi
Rakesh K. Tekade
ResearchOpen Access05 Nov 2019
Scientific Reports

Volume: 9, P: 1-18
Biomechanical Evaluation of Wasp and Honeybee Stingers

Rakesh Das
Ram Naresh Yadav
Bharat Bhushan
ResearchOpen Access08 Oct 2018
Scientific Reports

Volume: 8, P: 1-13
NeuroPIpred: a tool to predict, design and scan insect neuropeptides

Piyush Agrawal
Sumit Kumar
Indrakant K. Singh
ResearchOpen Access26 Mar 2019
Scientific Reports

Volume: 9, P: 1-12
A functional genetic screen defines the AKT-induced senescence signaling network

Keefe T. Chan
Shaun Blake
Richard B. Pearson
ResearchOpen Access08 Jul 2019
Cell Death & Differentiation

Volume: 27, P: 725-741
Producer organizations in the last 25 years: a bibliometric analysis and meta-review of the literature

Shantanu Bhunia
Piyush Kumar Singh
ReviewsOpen Access13 Feb 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-12

Search

Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms

CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade

Comparative metagenomic analysis of the oral microbiome in COVID-19 patients and healthy individuals

High accuracy indoor positioning system using Galois field-based cryptography and hybrid deep learning

YBa₂Cu₃O₇ as a high-temperature superinductor

Instagram fake profile detection using an ensemble learning method

IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma

An African vulture optimization algorithm based energy efficient clustering scheme in wireless sensor networks

In vivo tumor immune microenvironment phenotypes correlate with inflammation and vasculature to predict immunotherapy response

Local immune response to food antigens drives meal-induced abdominal pain

Evaluating the detectability of methane point sources from satellite observing systems using microscale modeling

Molecular dynamics simulation and docking studies reveals inhibition of NF-kB signaling as a promising therapeutic drug target for reduction in cytokines storms

An immunodominant NP_105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease

Vaccination to prevent T cell subversion can protect against persistent hepacivirus infection

Assessment of antibacterial, nematicidal and herbicidal activities of Cautleya spicata (Sm.) Baker extracts, with chemical profiling using GC-MS

CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production

PEPlife: A Repository of the Half-life of Peptides

The role of generative AI tools in shaping mechanical engineering education from an undergraduate perspective

Advances to IoT security using a GRU-CNN deep learning model trained on SUCMO algorithm

Physicochemical and biological analysis of river Yamuna at Palla station from 2009 to 2019

Spectroscopic insight into breast cancer: profiling small extracellular vesicles lipids via infrared spectroscopy for diagnostic precision

Applying YOLOv6 as an ensemble federated learning framework to classify breast cancer pathology images

ChaQra: a cellular unit of the Indian quantum network

Understanding non-stationarity of hydroclimatic extremes and resilience in Peninsular catchments, India

Geospatial data for peer-to-peer communication among autonomous vehicles using optimized machine learning algorithm

Towards in vitro models for reducing or replacing the use of animals in drug testing

Comment on: ‘Prevalence of co-existent neoplasia in clinically diagnosed pterygia in a UK population’

Method and its Composition for encapsulation, stabilization, and delivery of siRNA in Anionic polymeric nanoplex: An In vitro- In vivo Assessment

Biomechanical Evaluation of Wasp and Honeybee Stingers

NeuroPIpred: a tool to predict, design and scan insect neuropeptides

A functional genetic screen defines the AKT-induced senescence signaling network

Producer organizations in the last 25 years: a bibliometric analysis and meta-review of the literature

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