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Showing 1–13 of 13 results
Advanced filters: Author: Placide Mbala-Kingebeni Clear advanced filters

  • Phylogeographic analysis of 792 Ebola virus genomes from the 2018 oubreak in the Democratic Republic of the Congo integrated into an end-to-end surveillance program demonstrates the feasibility of using genomic sequencing data to inform the public health epidemic response in near-real time.

    • Eddy Kinganda-Lusamaki
    • Allison Black
    • Jean-Jacques Muyembe Tamfum
    Research
    Nature Medicine
    Volume: 27, P: 710-716

  • Analysis reveals commercial tests for Ebola are too hard to come by in the current outbreak — sustain investment, urge Lieselotte Cnops, Kevin K. Ariën and colleagues.

    • Lieselotte Cnops
    • Birgit De Smet
    • Kevin K. Ariën
    Comments & Opinion
    Nature
    Volume: 565, P: 419-421

  • High-income countries have a wealth of genomics expertise that can be rapidly activated to deal with disease threats. African countries should invest in a federated data-management system for genomics epidemiology to deal with such threats better.

    • Alan Christoffels
    • Gerald Mboowa
    • Yenew Kebede Tebeje
    Comments & Opinion
    Nature Medicine
    Volume: 29, P: 1052-1055

  • This study describes a new method that improves the sensitivity of viral detection compared with next-generation sequencing and enables the detection of emerging flaviviruses not specifically targeted a priori. Metagenomic sequencing with spiked primer enrichment is simple, low cost, fast and deployable on either benchtop or portable nanopore sequencers, making it applicable for diagnostic laboratory and field use.

    • Xianding Deng
    • Asmeeta Achari
    • Charles Y. Chiu
    Research
    Nature Microbiology
    Volume: 5, P: 443-454

  • An analysis of all available mpox virus sequences, including 10,670 sequences from 65 countries collected between 1958 and 2024, unveils the circulation pattern and spatiotemporal dynamics underlying the spread of the different viral clades.

    • James R. Otieno
    • Christopher Ruis
    • Lorenzo Subissi
    ResearchOpen Access
    Nature Medicine
    Volume: 31, P: 342-350

  • Imani-Musimwa et al. describe the precarious situation in the DRC, exacerbated by armed conflict, poor infrastructure, and limited healthcare resources, and call for urgent action to enhance Mpox testing and control efforts, which could significantly reduce the outbreak’s impact and improve health security in Africa.

    • Prince Imani-Musimwa
    • Placide Mbala-Kingebeni
    • Mija Ververs
    Comments & OpinionOpen Access
    Communications Medicine
    Volume: 5, P: 1-3

  • Currently Central Africa is experiencing multiple large concurrent mpox outbreaks spreading across several nations and at-risk populations via multiple transmission modes. This current surge of cases, framed in the context of the 2022 global outbreak, is challenging legacy understandings of mpox. Here, we consider how the political, economic, and public health conditions of the Democratic Republic of the Congo have influenced the recorded epidemiology of mpox and how, given this context, current vaccine and outbreak response can be crafted for greatest impact.

    • Megan Halbrook
    • Jean Claude Makangara-Cigolo
    • Jason Kindrachuk
    Comments & OpinionOpen Access
    npj Viruses
    Volume: 2, P: 1-4