Glycine-alanine dipeptide repeats produced by the C9orf72 gene are proposed to cause neurotoxicity in related diseases, but is challenging to study experimentally. Here a photolabile cell-penetrating peptide allows superresolution imaging of the distribution and aggregation of a simple dipeptide which recapitulates neurotoxicity associated with endogenous analogues.
- Hung-Ming Chien
- Ruei-Yu He
- Joseph Jen-Tse Huang
