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Showing 1–4 of 4 results

Advanced filters: Author: Pol Margalef Clear advanced filters

Erratum: Molecular basis of telomere dysfunction in human genetic diseases

Grzegorz Sarek
Paulina Marzec
Simon J Boulton
Amendments and Corrections06 Jun 2017
Nature Structural & Molecular Biology

Volume: 24, P: 553
IKKα is required in the intestinal epithelial cells for tumour stemness

Carlota Colomer
Pol Margalef
Lluis Espinosa
ResearchOpen Access13 Feb 2018
British Journal of Cancer

Volume: 118, P: 839-846
CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle

A phospho-switch is identified in the shelterin subunit TRF2 that regulates transient recruitment of the RTEL1 helicase to, and release from, telomeres, and provides a narrow window during which RTEL1 can unwind t-loops to facilitate telomere replication.

Grzegorz Sarek
Panagiotis Kotsantis
Simon J. Boulton
Research13 Nov 2019
Nature

Volume: 575, P: 523-527
Molecular basis of telomere dysfunction in human genetic diseases

Genetic mutations that compromise telomere-length maintenance give rise to a group of related human diseases called telomere biology disorders. This Review discusses the molecular functions impaired by disease-associated mutations as well as modes of inheritance and clinical manifestations.

Grzegorz Sarek
Paulina Marzec
Simon J Boulton
Reviews04 Nov 2015
Nature Structural & Molecular Biology

Volume: 22, P: 867-874