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Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy

Mechanisms of non-response to ustekinumab, a biologic targeting IL-23, are currently unclear. Here, the authors show that the transcriptional program regulated by IL-22, an IL-23 responsive cytokine, is enriched in patients with ulcerative colitis unresponsive to ustekinumab and associated with higher colon neutrophil recruitment and activation of upstream IL-22 regulators.

Polychronis Pavlidis
Anastasia Tsakmaki
Nick Powell
ResearchOpen Access03 Oct 2022
Nature Communications

Volume: 13, P: 1-17
Gastrointestinal toxicity of immune checkpoint inhibitors: from mechanisms to management

Immune checkpoint inhibitors are a novel approach to cancer immunotherapy. However, they are associated with substantial risk of immune-related adverse events, including gastrointestinal toxicity. This Review explores the manifestations of gastrointestinal toxicity with immune checkpoint inhibitor use and insights into its management.

Mark A. Samaan
Polychronis Pavlidis
Peter M. Irving
Reviews07 Mar 2018
Nature Reviews Gastroenterology & Hepatology

Volume: 15, P: 222-234
Human retinoic acid–regulated CD161⁺ regulatory T cells support wound repair in intestinal mucosa

T_reg cells are essential for enforcing peripheral tolerance but can also influence tissue regeneration. Afzali and colleagues use high-dimensional analysis to describe a distinct population of CD161⁺ human T_reg cells involved in wound healing of the intestinal mucosa.

Giovanni A. M. Povoleri
Estefania Nova-Lamperti
Behdad Afzali
Research05 Nov 2018
Nature Immunology

Volume: 19, P: 1403-1414
Complement receptor CD46 co-stimulates optimal human CD8⁺ T cell effector function via fatty acid metabolism

Complement, while serving to remove pathogens in the circulation, is also important for synergizing with inflammasomes to modulate CD4 T cell activation. Here the authors show that CD46, a complement receptor expressed only in humans, is essential for inducing optimal activation and effector functions of human CD8 T cells.

Giuseppina Arbore
Erin E. West
Claudia Kemper
ResearchOpen Access10 Oct 2018
Nature Communications

Volume: 9, P: 1-15
Automated decision making in Barrett’s oesophagus: development and deployment of a natural language processing tool

Agathe Zecevic
Laurence Jackson
Sebastian S. Zeki
ResearchOpen Access07 Nov 2024
npj Digital Medicine

Volume: 7, P: 1-9

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Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy

Gastrointestinal toxicity of immune checkpoint inhibitors: from mechanisms to management

Human retinoic acid–regulated CD161+ regulatory T cells support wound repair in intestinal mucosa

Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism

Automated decision making in Barrett’s oesophagus: development and deployment of a natural language processing tool

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Human retinoic acid–regulated CD161⁺ regulatory T cells support wound repair in intestinal mucosa

Complement receptor CD46 co-stimulates optimal human CD8⁺ T cell effector function via fatty acid metabolism