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N1-Methylpseudouridine and pseudouridine modifications modulate mRNA decoding during translation

Chemical modification of mRNA nucleobases alters hydrogen bonding during translation. Here the authors show that the N1-methylpseudouridine (m1ψ), used in therapeutics, does not change translation rate but modestly modulates its fidelity in a codon-position and tRNA dependent manner.

Jeremy Monroe
Daniel E. Eyler
Kristin S. Koutmou
ResearchOpen Access16 Sept 2024
Nature Communications

Volume: 15, P: 1-11
Streptomyces umbrella toxin particles block hyphal growth of competing species

Streptomyces are discovered to produce antibacterial protein complexes that selectively inhibit the hyphal growth of related species, a function distinct from that of the small-molecule antibiotics they are known for.

Qinqin Zhao
Savannah Bertolli
Joseph D. Mougous
ResearchOpen Access17 Apr 2024
Nature

Volume: 629, P: 165-173
trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo

Antibiotic-resistant bacterial pathogens pose a substantial threat to human health. Here, aided by structural analyses, the authors describe the molecular mechanism behind the activity of a series of compounds that inhibit trans-translation and are effective in eradicating N. gonorrhoeae infection in mice.

Zachary D. Aron
Atousa Mehrani
Kenneth C. Keiler
ResearchOpen Access19 Mar 2021
Nature Communications

Volume: 12, P: 1-12
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22

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N1-Methylpseudouridine and pseudouridine modifications modulate mRNA decoding during translation

Streptomyces umbrella toxin particles block hyphal growth of competing species

trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo

At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

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N1-Methylpseudouridine and pseudouridine modifications modulate mRNA decoding during translation

Streptomyces umbrella toxin particles block hyphal growth of competing species

trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo

At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

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