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Showing 1–6 of 6 results
Advanced filters: Author: Pornpimol Charoentong Clear advanced filters

  • Cancer immunotherapies are promising strategies for cancer treatment. However, their optimized use will require a comprehensive understanding of the diverse cell types, antigens and genetic variants (both germline and somatic) that comprise the tumour–immune system interface. This Review discusses various bioinformatics tools that process multi-level omics data for insights into tumour–immune cell interactions.

    • Hubert Hackl
    • Pornpimol Charoentong
    • Zlatko Trajanoski
    Reviews
    Nature Reviews Genetics
    Volume: 17, P: 441-458

  • The re-wiring of the metabolic machinery is a common feature in cancer. Here, the authors show, using paired normal and prostate cancer samples that the cancer samples exhibit a shift to succinate respiration, which is associated with elevated levels of mitochondrial DNA mutations.

    • Bernd Schöpf
    • Hansi Weissensteiner
    • Helmut Klocker
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • The cancer immunoediting hypothesis assumes the immune system sculpts the cancer genome. Here the authors show, in a mouse model, that neutral evolution outweighs the effects of immunoselection and that immune checkpoint blockade potentiates the immunoediting, switching the system to non-neutral evolution.

    • Mirjana Efremova
    • Dietmar Rieder
    • Zlatko Trajanoski
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Pflügler, Svinka et al. identify a subset of Paneth cells in mouse intestinal crypts and tumors, which express the immune checkpoint molecule Ido1 in a Stat1-dependent manner and promote tumor growth. Gene expression data from human colorectal cancer (CRC) suggest that a similar population is present in human cancer and opens the door for further studies of immune escape mechanisms in CRC.

    • Sandra Pflügler
    • Jasmin Svinka
    • Robert Eferl
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-14