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The formation of the ‘footprint of death’ as a mechanism for generating large substrate-bound extracellular vesicles that mark the site of cell death

Apoptotic cells often release extracellular vesicles that aid in their clearance and provide molecular information to cellular neighbours. Here, the authors show that some adherent apoptotic cells also create vesicles that remain attached at the site of death.

Stephanie F. Rutter
Taeyoung Kang
Ivan K. H. Poon
ResearchOpen Access15 Oct 2025
Nature Communications

Volume: 16, P: 1-15
Author Correction: In situ visualization of endothelial cell-derived extracellular vesicle formation in steady state and malignant conditions

Georgia K. Atkin-Smith
Jascinta P. Santavanond
Ivan K. H. Poon
Amendments and CorrectionsOpen Access03 Oct 2025
Nature Communications

Volume: 16, P: 1
In situ visualization of endothelial cell-derived extracellular vesicle formation in steady state and malignant conditions

The extrusion of large extracellular vesicles is an important mechanism that facilitates cell-to-cell communication and maintains homoeostasis. Here, Atkin-Smith et al. use intravital microscopy to directly visualize the formation of large extracellular vesicles in bone marrow.

Georgia K. Atkin-Smith
Jascinta P. Santavanond
Ivan K. H. Poon
ResearchOpen Access22 Oct 2024
Nature Communications

Volume: 15, P: 1-18
Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutation carriers

Joyce, Pascual et al. identify luminal progenitors as likely cells-of-origin in BRCA2-mutant breast cancer, exhibiting dysregulated proteostasis and translation, which may be therapeutically targeted via mTORC1 inhibition.

Rachel Joyce
Rosa Pascual
Jane E. Visvader
Research12 Jan 2024
Nature Cell Biology

Volume: 26, P: 138-152
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Vaccination is effective in protecting from COVID-19. Here the authors report immune responses and breakthrough infections in twice-vaccinated patients receiving anti-TNF treatments for inflammatory bowel disease, and find dampened vaccine responses that implicate the need of adapted vaccination schedules for these patients.

Simeng Lin
Nicholas A. Kennedy
Jeannie Bishop
ResearchOpen Access16 Mar 2022
Nature Communications

Volume: 13, P: 1-14
Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice

Serotonin (5-HT) is an important mediator of tissue edema and inflammation. The authors used mouse models and cell-based signaling assays to provide greater understanding of the mechanisms involved. They demonstrate that effects of 5-HT are mediated through the 5-HT_2A receptor and involve activation of the mechanosensitive ion channel TRPV4 and neuropeptide release.

Jeffri S. Retamal
Megan S. Grace
Peter McIntyre
Research15 Apr 2021
Laboratory Investigation

Volume: 101, P: 851-864

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The formation of the ‘footprint of death’ as a mechanism for generating large substrate-bound extracellular vesicles that mark the site of cell death

Author Correction: In situ visualization of endothelial cell-derived extracellular vesicle formation in steady state and malignant conditions

In situ visualization of endothelial cell-derived extracellular vesicle formation in steady state and malignant conditions

Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutation carriers

Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice

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The formation of the ‘footprint of death’ as a mechanism for generating large substrate-bound extracellular vesicles that mark the site of cell death

Author Correction: In situ visualization of endothelial cell-derived extracellular vesicle formation in steady state and malignant conditions

In situ visualization of endothelial cell-derived extracellular vesicle formation in steady state and malignant conditions

Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutation carriers

Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice

Search

Quick links