Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–4 of 4 results
Advanced filters: Author: Prakash Rucktooa Clear advanced filters

  • Neurokinin receptors are G protein-coupled receptors. Here the authors present three crystal structures of the neurokinin 1 receptor (NK1R) in complex with small-molecule antagonists including aprepitant and netupitant and observe that these clinically approved compounds induce a conformational change in the receptor.

    • Jendrik Schöppe
    • Janosch Ehrenmann
    • Andreas Plückthun
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Mediator is a large multi-subunits complex essential to the regulation of transcription by RNA pol II. Here the authors report the crystal structure of MED23—one of the largest subunits of the complex together with MED1 and MED14—revealing a complex architecture and filling an important gap in the structural characterization of Mediator.

    • Didier Monté
    • Bernard Clantin
    • Vincent Villeret
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-7

  • AChBP is used as a structurally accessible prototype for studying ligand binding to nicotinic acetylcholine receptors. Stornaiuolo et al. report that a small molecule binds AChBP in an ordered p–p stack of three molecules per binding site, which may lead to new approaches in drug design.

    • Mariano Stornaiuolo
    • Gerdien E. De Kloe
    • Titia K. Sixma
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-11