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Showing 1–2 of 2 results
Advanced filters: Author: Pranitha Vangala Clear advanced filters

  • HIV-1 infection is associated with persistent inflammation that can contribute to a variety of comorbidities. Luban and colleagues demonstrate that HIV-1 infection results in permanent depletion of innate lymphoid cells, leading to breakdown of gut barrier function and a feed-forward inflammation loop, which includes skewing of NK cells toward an inflammatory/memory phenotype.

    • Yetao Wang
    • Lawrence Lifshitz
    • Jeremy Luban
    Research
    Nature Immunology
    Volume: 21, P: 274-286

  • Atherosclerosis is an inflammatory disease with limited therapeutic options. Here, the authors show that protein kinase MAP4K4 regulates vascular inflammation underlying atherosclerotic plaque development and that its inhibition prevents the disease and promotes lesion regression in mice, proposing a new atherosclerosis treatment.

    • Rachel J. Roth Flach
    • Athanasia Skoura
    • Michael P. Czech
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11