Nature Search

c-Kit signaling potentiates CAR T cell efficacy in solid tumors by CD28- and IL-2-independent co-stimulation

Xiong et al. engineer CAR T cells to express the c-Kit D816V mutation, which enhances antigen-dependent proliferation and cytotoxicity, translates into extended survival in solid tumor models and is controllable by tyrosine kinase inhibitors.

Yuquan Xiong
Meriem Taleb
Prasad S. Adusumilli
Research19 Jun 2023
Nature Cancer

Volume: 4, P: 1001-1015
Evolutionary characterization of lung adenocarcinoma morphology in TRACERx

Analyses of the TRACERx study unveil the relationship between tissue morphology, the underlying evolutionary genomic landscape, and clinical and anatomical relapse risk of lung adenocarcinomas.

Takahiro Karasaki
David A. Moore
Mariam Jamal-Hanjani
Research12 Apr 2023
Nature Medicine

Volume: 29, P: 833-845
Improved prediction of immune checkpoint blockade efficacy across multiple cancer types

A combination of genomic and clinical features improves predictions of response to immune checkpoint blockade.

Diego Chowell
Seong-Keun Yoo
Timothy A. Chan
Research01 Nov 2021
Nature Biotechnology

Volume: 40, P: 499-506
Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors

There is an unmet clinical need for simple, accessible biomarkers to select patients who are more likely to respond to immune checkpoint therapy. Here the authors show that a lower neutrophil-to-lymphocyte ratio is associated with better overall and progressive-free survival, as well as higher rate of response, in a multi-cancer cohort of patients treated with immune checkpoint inhibitors.

Cristina Valero
Mark Lee
Luc G. T. Morris
ResearchOpen Access01 Feb 2021
Nature Communications

Volume: 12, P: 1-9
V-domain Ig-containing suppressor of T-cell activation (VISTA), a potentially targetable immune checkpoint molecule, is highly expressed in epithelioid malignant pleural mesothelioma

Stephanie Muller
W. Victoria Lai
Jennifer L. Sauter
Research19 Sept 2019
Modern Pathology

Volume: 33, P: 303-311
Arming T cells to infiltrate pancreatic tumours

The efficacy of adoptive cell therapy for pancreatic cancer can be augmented by antigen-specific cytotoxic T cells genetically engineered to overexpress a C-X-C chemokine receptor whose ligand is highly expressed by pancreatic cancer cells.

Leonid Cherkassky
Prasad S. Adusumilli
News & Views12 Nov 2021
Nature Biomedical Engineering

Volume: 5, P: 1243-1245
Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status"

Lindsay M LaFave
Wendy Béguelin
Ross L Levine
Correspondence07 Jun 2016
Nature Medicine

Volume: 22, P: 578-579
Loss of BAP1 function leads to EZH2-dependent transformation

BAP1 regulation of EZH2 provides therapeutic opportunities in cancer.

Lindsay M LaFave
Wendy Béguelin
Ross L Levine
Research05 Oct 2015
Nature Medicine

Volume: 21, P: 1344-1349
Comparative analysis of assays to measure CAR T-cell-mediated cytotoxicity

In this review article, the authors compare in vitro cytotoxicity assays (including chromium release, bioluminescence, impedance and flow cytometry assays) with respect to their experimental setup, appropriate uses, advantages and disadvantages and measures to overcome their limitations.

Stefan Kiesgen
John C. Messinger
Prasad S. Adusumilli
Reviews15 Feb 2021
Nature Protocols

Volume: 16, P: 1331-1342
Preoperative clinical and tumor genomic features associated with pathologic lymph node metastasis in clinical stage I and II lung adenocarcinoma

Raul Caso
James G. Connolly
David R. Jones
ResearchOpen Access21 Jul 2021
npj Precision Oncology

Volume: 5, P: 1-8
Nuclear grade and necrosis predict prognosis in malignant epithelioid pleural mesothelioma: a multi-institutional study

Lauren E Rosen
Theodore Karrison
Aliya N Husain
Research12 Jan 2018
Modern Pathology

Volume: 31, P: 598-606
Pulmonary large cell neuroendocrine carcinoma with adenocarcinoma-like features: napsin A expression and genomic alterations

Natasha Rekhtman
Catherine M Pietanza
Philippe Joubert
Research08 Sept 2017
Modern Pathology

Volume: 31, P: 111-121
A nuclear grading system is a strong predictor of survival in epitheloid diffuse malignant pleural mesothelioma

Kyuichi Kadota
Kei Suzuki
Prasad S Adusumilli
Research07 Oct 2011
Modern Pathology

Volume: 25, P: 260-271
A grading system combining architectural features and mitotic count predicts recurrence in stage I lung adenocarcinoma

Kyuichi Kadota
Kei Suzuki
William D Travis
Research13 Apr 2012
Modern Pathology

Volume: 25, P: 1117-1127
The cribriform pattern identifies a subset of acinar predominant tumors with poor prognosis in patients with stage I lung adenocarcinoma: a conceptual proposal to classify cribriform predominant tumors as a distinct histologic subtype

Kyuichi Kadota
Yi-Chen Yeh
William D Travis
Research01 Nov 2013
Modern Pathology

Volume: 27, P: 690-700

Search

c-Kit signaling potentiates CAR T cell efficacy in solid tumors by CD28- and IL-2-independent co-stimulation

Evolutionary characterization of lung adenocarcinoma morphology in TRACERx

Improved prediction of immune checkpoint blockade efficacy across multiple cancer types

Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors

V-domain Ig-containing suppressor of T-cell activation (VISTA), a potentially targetable immune checkpoint molecule, is highly expressed in epithelioid malignant pleural mesothelioma

Arming T cells to infiltrate pancreatic tumours

Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status"

Loss of BAP1 function leads to EZH2-dependent transformation

Comparative analysis of assays to measure CAR T-cell-mediated cytotoxicity

Preoperative clinical and tumor genomic features associated with pathologic lymph node metastasis in clinical stage I and II lung adenocarcinoma

Nuclear grade and necrosis predict prognosis in malignant epithelioid pleural mesothelioma: a multi-institutional study

Pulmonary large cell neuroendocrine carcinoma with adenocarcinoma-like features: napsin A expression and genomic alterations

A nuclear grading system is a strong predictor of survival in epitheloid diffuse malignant pleural mesothelioma

A grading system combining architectural features and mitotic count predicts recurrence in stage I lung adenocarcinoma

The cribriform pattern identifies a subset of acinar predominant tumors with poor prognosis in patients with stage I lung adenocarcinoma: a conceptual proposal to classify cribriform predominant tumors as a distinct histologic subtype

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