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Showing 1–10 of 10 results
Advanced filters: Author: Prathapan Thiru Clear advanced filters

  • Mitochondrial energy metabolism regulates proteotoxic stress tolerance, exposing a newly discovered sensitivity to the small molecule elesclomol, which induces FDX1-mediated, copper-dependent cell death.

    • Peter Tsvetkov
    • Alexandre Detappe
    • Todd R. Golub
    Research
    Nature Chemical Biology
    Volume: 15, P: 681-689

  • Spleen protein tyrosine kinase (Syk) has so far been mainly studied in haematopoietic and immune cells. Here, the authors show that Syk also has a role in brown adipose tissue, where it regulates the formation of brown adipocytes and their thermogenic activation in response to β-adrenergic stimulation.

    • Marko Knoll
    • Sally Winther
    • Harvey F. Lodish
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • LACTB modulates mitochondrial lipid metabolism and changes the differentiation state of breast cancer cells, thereby negatively affecting the growth of various tumorigenic, but not non-tumorigenic, cells both in vitro and in vivo.

    • Zuzana Keckesova
    • Joana Liu Donaher
    • Robert A. Weinberg
    Research
    Nature
    Volume: 543, P: 681-686

  • New apparatus is used to maintain proliferating cancer cells in low-glucose conditions, demonstrating that mitochondrial oxidative phosphorylation (OXPHOS) is essential for optimal proliferation in these conditions; the most sensitive cell lines are defective in OXPHOS upregulation and may therefore be sensitive to current antidiabetic drugs that inhibit OXPHOS.

    • Kıvanç Birsoy
    • Richard Possemato
    • David M. Sabatini
    Research
    Nature
    Volume: 508, P: 108-112

  • Under stress conditions such as acute blood loss or chronic anaemia, glucocorticoids trigger self-renewal of early burst-forming unit–erythroid (BFU–E) progenitors in the spleen, however, the mechanism of glucocorticoid action is not well understood; here the RNA binding protein ZFP36L2 is identified as a transcriptional target of the glucocorticoid receptor in BFU-Es and is shown to be involved in the process of erythroid cell expansion following exposure to glucocorticoids.

    • Lingbo Zhang
    • Lina Prak
    • Harvey F. Lodish
    Research
    Nature
    Volume: 499, P: 92-96

  • Ribosomal protein deficiency in Diamond-Blackfan anemia impairs protein translation of the key erythroid transcription factor GATA1.

    • Leif S Ludwig
    • Hanna T Gazda
    • Vijay G Sankaran
    Research
    Nature Medicine
    Volume: 20, P: 748-753

  • Platypuses are monotremes and combine aspects of both reptilian and mammalian behaviour. An international consortium reports the genome sequence and analysis of Ornithorhynchus anatinus and as expected, parts of the genome look more like mammals, whereas other parts more like reptiles or even chickens.

    • Wesley C. Warren
    • LaDeana W. Hillier
    • Richard K. Wilson
    ResearchOpen Access
    Nature
    Volume: 453, P: 175-183