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Advanced filters: Author: Preeti Paliwal Clear advanced filters

Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy

Hartman et al. use mouse models of cardiac function to show that aficamten decreases the availability of myosin heads for contraction during systole, attenuating a primary driver of hypertrophic cardiomyopathy pathophysiology.

James J. Hartman
Darren T. Hwee
Fady I. Malik
ResearchOpen Access23 Jul 2024
Nature Cardiovascular Research

Volume: 3, P: 1003-1016
Investigation, scaffold hopping of novel donepezil-based compounds as anti-Alzhiemer’s agents: synthesis, in-silico and pharmacological evaluations

Mohan Gupta
Swati Pant
Sumitra Nain
ResearchOpen Access19 Jan 2024
Scientific Reports

Volume: 14, P: 1-14

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Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy

Investigation, scaffold hopping of novel donepezil-based compounds as anti-Alzhiemer’s agents: synthesis, in-silico and pharmacological evaluations

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