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Showing 1–2 of 2 results
Advanced filters: Author: Pritika Narayan Clear advanced filters

  • Although Huntington’s disease (HD) is a well-studied genetic disorder, less is known about the epigenetic changes underlying it. Here, the authors characterize DNA methylation levels in tissues from patients, a mouse huntingtin (Htt) gene knock-in model, and a transgenic HTT sheep model, and provide evidence that HD is accompanied by DNA methylation changes in these three species.

    • Ake T. Lu
    • Pritika Narayan
    • Steve Horvath
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Smyth et al. use tissue microarrays from Alzheimer’s disease (AD) patient brains to show that PDGF-BB:PDGFRβ signalling components are reduced in AD. They then use primary human brain pericytes to elucidate a pathway by which PDGF-BB:PDGFRβ signalling in brain pericytes is disrupted in AD, thus impairing the blood brain barrier.

    • Leon C. D. Smyth
    • Blake Highet
    • Mike Dragunow
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-16