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Advanced filters: Author: Purui Yan Clear advanced filters

Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system

Structural analysis of Crenotalea thermophila SPARTA reveals that guide-mediated target binding releases the auto-inhibition of SPARTA imposed by an acidic tail and triggers substantial conformational changes, resulting in the oligomerization of short Ago and TIR for SPARTA activation.

Lijie Guo
Pingping Huang
Yibei Xiao
Research06 Nov 2023
Nature Chemical Biology

Volume: 20, P: 512-520
The mechanism of bacterial defense system DdmDE from Lactobacillus casei

Pingping Huang
Purui Yan
Meirong Chen
Correspondence24 Oct 2024
Cell Research

Volume: 34, P: 873-876

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Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system

The mechanism of bacterial defense system DdmDE from Lactobacillus casei

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