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Showing 1–6 of 6 results
Advanced filters: Author: Pushkar Ramesh Clear advanced filters

  • Here the authors map mesothelial cells across organs, revealing conserved disease-driven states. They identify key genes controlling the shift toward fibrosis and shows that blocking this reprogramming protects lungs, opening new anti-fibrosis strategies.

    • Safwen Kadri
    • Adrian Fischer
    • Yuval Rinkevich
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Extensive scars develop in deep wounds as opposed to superficial wounds but it is unclear why. Here, the authors use live imaging of physiologic wounds and scars formed ex vivo to show that fascia fibroblasts upregulate N-cadherin allowing coordinated cell migration that drives extensive scar formation of deep wounds.

    • Dongsheng Jiang
    • Simon Christ
    • Yuval Rinkevich
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Adipocyte plasticity during injury repair is debated. Here, the authors find that injury causes temporary adipocyte migration, but without lineage conversion to myofibroblasts. Distinct migration patterns, transcriptomics and ECM depositions indicate that adipocytes, unlike fibroblasts, do not contribute to fibrotic scars.

    • Shruthi Kalgudde Gopal
    • Ruoxuan Dai
    • Yuval Rinkevich
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Cells that populate scar tissue in mammalian skin migrate to wounds as prefabricated matrix from the subcutaneous fascia, including embedded blood vessels, macrophages and peripheral nerves.

    • Donovan Correa-Gallegos
    • Dongsheng Jiang
    • Yuval Rinkevich
    Research
    Nature
    Volume: 576, P: 287-292