Jung-Eun Lee et al. show that aged mice have increased oxidative stress and NADPH activity in the hippocampus which is associated with increased susceptibility to stress. Upregulation of NADPH oxidase, due to sustained p47phox expression, was caused by a decrease in SUV39H1 levels, highlighting an important mechanism regulating aging-induced stress susceptibility.
- Jung-Eun Lee
- Hye-Jin Kwon
- Pyung-Lim Han