Nature Search

Pathologist-like explainable AI for interpretable Gleason grading in prostate cancer

An inherently explainable AI trained on 1,015 expert-annotated prostate tissue images achieved strong Gleason pattern segmentation while providing interpretable outputs and addressing interobserver variability in pathology.

Gesa Mittmann
Sara Laiouar-Pedari
Titus J. Brinker
ResearchOpen Access08 Oct 2025
Nature Communications

Volume: 16, P: 1-17
Evidence of air-induced surface transformation of atomic step-engineered sapphire in relation to epitaxial growth of 2D semiconductors

The growth of wafer-scale single-crystalline 2D semiconductors on sapphire is important for their electronic applications, but the underlying mechanisms are not yet fully understood. Here, the authors study the influence of air-induced sapphire surface hydrolysis on the growth process of 2D WS₂ and propose an ultraviolet light healing method to repair the degraded substrates.

Wei Fu
Jianwei Chai
Kuan Eng Johnson Goh
ResearchOpen Access26 Sept 2025
Nature Communications

Volume: 16, P: 1-12
Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

A multi-ancestry genome-wide gene–smoking interaction study identifies 13 new loci associated with serum lipids.

Amy R. Bentley
Yun J. Sung
L. Adrienne Cupples
Research29 Mar 2019
Nature Genetics

Volume: 51, P: 636-648
Milestone in predicting core plasma turbulence: successful multi-channel validation of the gyrokinetic code GENE

Plasma turbulence is the main driver to deteriorate the performance of fusion power plants. This work presents an unprecedented comparison of plasma turbulence between experiment and simulation, proving that the gyrokinetic model GENE reached a high level of maturity to predict core turbulence.

Klara Höfler
Tobias Görler
S. Zoletnik
ResearchOpen Access15 Mar 2025
Nature Communications

Volume: 16, P: 1-11
Observation of magnetic islands in tokamak plasmas during the suppression of edge-localized modes

The suppression of edge-localized modes in tokamak plasmas is crucial to prevent them from damaging the walls of the chamber. Now experiments confirm the role that magnetic islands play in suppressing these detrimental modes.

Matthias Willensdorfer
Verena Mitterauer
S. Zoletnik
ResearchOpen Access28 Oct 2024
Nature Physics

Volume: 20, P: 1980-1988
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

Urinary albumin-to-creatinine ratio (UCAR) is associated with various clinical outcomes such as kidney disease and cardiovascular disease. Here, the authors report genome-wide meta-analysis in over 500,000 individuals and find 68 UACR loci, followed by statistical fine-mapping, gene prioritization and experimental validation in flies.

Alexander Teumer
Yong Li
Anna Köttgen
ResearchOpen Access11 Sept 2019
Nature Communications

Volume: 10, P: 1-19
A catalog of genetic loci associated with kidney function from analyses of a million individuals

Trans-ancestry meta-analysis of estimated glomerular filtration rate (eGFR) from 1,046,070 individuals identifies 264 associated loci, providing a resource of molecular targets for translational research of chronic kidney disease.

Matthias Wuttke
Yong Li
Cristian Pattaro
Research31 May 2019
Nature Genetics

Volume: 51, P: 957-972
Magnetic domains and domain wall pinning in atomically thin CrBr₃ revealed by nanoscale imaging

Van der Waals (vdW) magnets have allowed researchers to explore the two dimensional limit of magnetisation; however experimental challenges have hindered analysis of magnetic domains. Here, using an NV centre based probe, the authors analyse the nature of magnetic domains in the vdW magnet, CrBr₃.

Qi-Chao Sun
Tiancheng Song
Jörg Wrachtrup
ResearchOpen Access31 Mar 2021
Nature Communications

Volume: 12, P: 1-7
Band structure engineering via piezoelectric fields in strained anisotropic CdSe/CdS nanocrystals

Quantum dots confine electrons to a nanometre length scale, and this gives rise to numerous quantum effects. Here, the authors directly control the excitonic structure of nanocrystal quantum dots by manipulating intra-particle piezoelectric fields.

Sotirios Christodoulou
Fernando Rajadell
Iwan Moreels
ResearchOpen Access29 Jul 2015
Nature Communications

Volume: 6, P: 1-8
KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease

The KL-VS haplotype of the Klotho gene has been associated with reduced risk of Alzheimer’s disease and dementia. Here the authors show an association between the KL-VS haplotype and amyloid-dependent tau accumulation using PET data.

Julia Neitzel
Nicolai Franzmeier
Michael Ewers
ResearchOpen Access22 Jun 2021
Nature Communications

Volume: 12, P: 1-12
Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Research06 May 2020
Nature

Volume: 583, P: 90-95
The return of long-lost Sumero-Akkadian heritage and modern disorders: rediscovering Gilgamesh, Victorian tension, and aftermath

Abdullah Qasim Safi Al-Hadi
Gao Xiaoling
ResearchOpen Access26 Jun 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-17
A variant in FTO shows association with melanoma risk not due to BMI

The GenoMEL consortium reports a genome-wide association study of melanoma based on imputation and identifies a variant in the FTO gene associated with susceptibility to melanoma.

Mark M Iles
Matthew H Law
Jennifer H Barrett
Research03 Mar 2013
Nature Genetics

Volume: 45, P: 428-432
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Amendments and Corrections17 Jul 2020
Nature

Volume: 584, P: E2
Making EuO multiferroic by epitaxial strain engineering

Multiferroics that are both ferroelectric and ferromagnetic are highly desirable for technological applications but extremely rare. Here, signatures of a ferroelectric phase transition, supported by theoretical calculations, are observed in ferromagnetic EuO under a large epitaxial strain of 6.4%.

Veronica Goian
Rainer Held
Stanislav Kamba
ResearchOpen Access14 Oct 2020
Communications Materials

Volume: 1, P: 1-10
Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

James H. R. Farmery
Mike L. Smith
Andy G. Lynch
ResearchOpen Access22 Jan 2018
Scientific Reports

Volume: 8, P: 1-17
Antidepressants recruit new neurons to improve stress response regulation

A Surget
A Tanti
C Belzung
ResearchOpen Access03 May 2011
Molecular Psychiatry

Volume: 16, P: 1177-1188
Tumor suppression in mice lacking GABARAP, an Atg8/LC3 family member implicated in autophagy, is associated with alterations in cytokine secretion and cell death

F S Salah
M Ebbinghaus
I Petersen
ResearchOpen Access28 Apr 2016
Cell Death & Disease

Volume: 7, P: e2205
Publisher Correction: Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

James H. R. Farmery
Mike L. Smith
Andy G. Lynch
Amendments and CorrectionsOpen Access03 Sept 2018
Scientific Reports

Volume: 8, P: 1-4

Search

Pathologist-like explainable AI for interpretable Gleason grading in prostate cancer

Evidence of air-induced surface transformation of atomic step-engineered sapphire in relation to epitaxial growth of 2D semiconductors

Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Milestone in predicting core plasma turbulence: successful multi-channel validation of the gyrokinetic code GENE

Observation of magnetic islands in tokamak plasmas during the suppression of edge-localized modes

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

A catalog of genetic loci associated with kidney function from analyses of a million individuals

Magnetic domains and domain wall pinning in atomically thin CrBr₃ revealed by nanoscale imaging

Band structure engineering via piezoelectric fields in strained anisotropic CdSe/CdS nanocrystals

KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease

Whole-genome sequencing of a sporadic primary immunodeficiency cohort

The return of long-lost Sumero-Akkadian heritage and modern disorders: rediscovering Gilgamesh, Victorian tension, and aftermath

A variant in FTO shows association with melanoma risk not due to BMI

Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Making EuO multiferroic by epitaxial strain engineering

Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

Antidepressants recruit new neurons to improve stress response regulation

Tumor suppression in mice lacking GABARAP, an Atg8/LC3 family member implicated in autophagy, is associated with alterations in cytokine secretion and cell death

Publisher Correction: Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

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