Iron oxide nanoparticles (IONP) are approved to treat iron deficiency and have been reported to reduce leukaemia in preclinical models. Here, the authors show that carboxymethyl dextran-coated IONP, but not other types of surface coating, activate the complement alternative pathway, enhancing macrophage phagocytosis and adaptive immunity to reduce leukaemia burden in mouse models.
- Yuanyuan Li
- Wen Wu
- Fangfang Chen
