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Showing 1–50 of 51 results

Advanced filters: Author: Qiming Zhou Clear advanced filters

Cholesterol sensing by the SCAP–FAM134B complex regulates ER-phagy and STING innate immunity

The authors show that the endoplasmic reticulum-phagy receptor FAM134B interacts with SCAP to regulate cholesterol biosynthesis, sequestering SCAP when endoplasmic reticulum cholesterol is high but dissociating upon low cholesterol levels, allowing SCAP to activate cholesterol synthesis.

Boran Li
Dongheng Zhou
Qiming Sun
Research13 Oct 2025
Nature Cell Biology

Volume: 27, P: 1739-1756
Natural variation in PTB1 regulates rice seed setting rate by controlling pollen tube growth

Understanding the genetic factors that regulate panicle architecture is important for improving rice yields. In this study, Li et al. demonstrate that the gene PTB1is critical for regulating panicle seed setting rate and pollen tube growth.

Shuangcheng Li
Wenbo Li
Ping Li
Research18 Nov 2013
Nature Communications

Volume: 4, P: 1-13
Rpl12 is a conserved ribophagy receptor

Chen, Hu, Zhao, Fang and colleagues show that the ribosomal large subunit protein Rpl12 functions as a conserved ribophagy receptor in multiple organisms.

Yuting Chen
Jiaxin Hu
Cong Yi
Research11 Feb 2025
Nature Cell Biology

Volume: 27, P: 477-492
Sphingosine-1-phosphate signalling activates E-Syt1 to facilitate HDL-derived cholesterol transport

Xu, Meng, St-Germain et al. report that S1P in HDL induces a calcium signalling cascade involving E-Syt1 that ultimately promotes the formation of contact sites between the endoplasmic reticulum and the plasma membrane, as well as HDL-derived cholesterol transport.

Zizhen Xu
Ying Meng
Dante Neculai
Research28 May 2025
Nature Cell Biology

Volume: 27, P: 918-930
Cryogenic in-memory computing using magnetic topological insulators

Material implementation of machine learning algorithms for advanced computing at cryogenic temperature remains rare. Here, the authors report a cryogenic in-memory computing platform using chiral edge states of magnetic topological insulators.

Yuting Liu
Albert Lee
Qiming Shao
Research27 Jan 2025
Nature Materials

Volume: 24, P: 559-564
Grapevine pangenome facilitates trait genetics and genomic breeding

By constructing a graph-based grapevine pangenome reference (Grapepan v.1.0) and incorporating structural variations and phenotypic maps, the study investigates the genetic basis of agronomic traits, empowering grapevine genomic breeding.

Zhongjie Liu
Nan Wang
Yongfeng Zhou
ResearchOpen Access04 Nov 2024
Nature Genetics

Volume: 56, P: 2804-2814
FairFML: fair federated machine learning with a case study on reducing gender disparities in cardiac arrest outcome prediction

Siqi Li
Qiming Wu
Nan Liu
ResearchOpen Access12 Aug 2025
npj Health Systems

Volume: 2, P: 1-8
Impacts of reproductive systems on grapevine genome and breeding

Effects of reproductive systems on crop genomic variation and breeding remain unclear. Here, the authors report that reproductive types impact genomic landscapes and grapevine breeding based on comparative genomic and population genetic analyses of wild grapevine and a complex pedigree of Pinot Noir.

Hua Xiao
Yue Wang
Yongfeng Zhou
ResearchOpen Access03 Mar 2025
Nature Communications

Volume: 16, P: 1-15
Atezolizumab plus bevacizumab and chemotherapy in metastatic nonsquamous NSCLC: the randomized double-blind phase 3 IMpower151 trial

In the IMpower151 trial, the drug combination previously shown to be effective in the IMpower150 trial was not significantly effective in a Chinese population.

Caicun Zhou
Xiaorong Dong
Minu K. Srivastava
ResearchOpen Access16 May 2025
Nature Medicine

Volume: 31, P: 2375-2384
SEAM is a spatial single nuclear metabolomics method for dissecting tissue microenvironment

SEAM is a platform for the analysis of high-resolution secondary ion mass spectrometry imaging that allows spatially resolved nuclear metabolomic profiling at the single-cell level.

Zhiyuan Yuan
Qiming Zhou
Michael Q. Zhang
Research04 Oct 2021
Nature Methods

Volume: 18, P: 1223-1232
OsSRF8 interacts with OsINP1 and OsDAF1 to regulate pollen aperture formation in rice

At the tetrad stage, OsSRF8 interacts with OsINP1 to promote the formation of aperture plasma membrane protrusion (APMP). Then, the OsINP1-OsSRF8 protein complex recruits OsDAF1 to the APMP site and co-regulate pollen aperture formation in rice.

Keyi Chen
Qiming Wang
Jianmin Wan
ResearchOpen Access27 May 2024
Nature Communications

Volume: 15, P: 1-14
A toxin-antidote system contributes to interspecific reproductive isolation in rice

Orzya meridionalis is a wild rice species that has reproductive isolation with Asian cultivated rice. Here, the authors report the cloning of the second locus controlling hybrid male sterility between the two species and show the encoded toxin-antidote system provides stacked reproductive isolation for maintaining species identity.

Shimin You
Zhigang Zhao
Jianmin Wan
ResearchOpen Access18 Nov 2023
Nature Communications

Volume: 14, P: 1-13
Benmelstobart, anlotinib and chemotherapy in extensive-stage small-cell lung cancer: a randomized phase 3 trial

In this triple-arm, placebo-controlled phase 3 trial, first-line treatment of patients with extensive-stage small-cell lung cancer with the anti-PD-L1 benmelstobart, tyrosine kinase inhibitor anlotinib and chemotherapy (CT) showed improved survival outcomes compared with anlotinib and CT or CT alone.

Ying Cheng
Jianhua Chen
Runxiang Yang
ResearchOpen Access11 Jul 2024
Nature Medicine

Volume: 30, P: 2967-2976
Continuous-wave near-infrared stimulated-emission depletion microscopy using downshifting lanthanide nanoparticles

The application of stimulated-emission depletion (STED) microscopy for deep-tissue imaging in the near-infrared optical window is challenged by high cellular autofluorescence. Here the authors present a lanthanide nanoprobe whose electronic configuration enables long-term STED imaging with reduced background noise.

Liangliang Liang
Ziwei Feng
Xiaogang Liu
Research14 Jun 2021
Nature Nanotechnology

Volume: 16, P: 975-980
Enhancing object pose estimation for RGB images in cluttered scenes

Metwalli Al-Selwi
Huang Ning
Jun Li
ResearchOpen Access13 Mar 2025
Scientific Reports

Volume: 15, P: 1-15
KSHV-encoded ORF45 activates human NLRP1 inflammasome

Liang and colleagues show that the ORF45 protein from the Kaposi’s sarcoma-associated herpesvirus activates NLRP1 by binding to its Linker1 region through a mechanism distinct from the previously described, host protease DPP9-dependent mechanism of NLRP1 activation.

Xing Yang
Jingfan Zhou
Qiming Liang
Research26 May 2022
Nature Immunology

Volume: 23, P: 916-926
Multimodal deep learning using on-chip diffractive optics with in situ training capability

Most photonic processors can only handle a single data modality due to the lack of abundant parameter training in optical domain. Here, authors propose and demonstrate a trainable diffractive optical neural network chip based on on-chip diffractive optics with tunable elements to address these constraints.

Junwei Cheng
Chaoran Huang
Xinliang Zhang
ResearchOpen Access23 Jul 2024
Nature Communications

Volume: 15, P: 1-10
Uncertainties in deforestation emission baseline methodologies and implications for carbon markets

This study reveals high variability in deforestation emission baselines typically used to derive carbon credits, with median error at 0.778 times the actual rate. It underscores the need for enhanced methods to improve carbon market accuracy and reliability.

Hoong Chen Teo
Nicole Hui Li Tan
Lian Pin Koh
ResearchOpen Access13 Dec 2023
Nature Communications

Volume: 14, P: 1-10
MAVS integrates glucose metabolism and RIG-I-like receptor signaling

MAVS is an adapter protein involved in RIG-I-like receptor (RLR) signaling. Here, the authors show how MAVS link RLR-mediated signaling and glucose metabolism, employing distinct mechanisms in different organelles.

Qiao-qiao He
Yu Huang
Shi Liu
ResearchOpen Access02 Sept 2023
Nature Communications

Volume: 14, P: 1-16
Hepatitis B virus rigs the cellular metabolome to avoid innate immune recognition

RIG-I is a cytosolic antiviral nucleic acid sensor that signals via MAVS to produce type 1 interferons. Here the authors show that hepatits B virus can repress this pathway by activating glycolysis and lactate production, enabling accumulated lactate to bind MAVS and prevent its mitochondrial localization.

Li Zhou
Rui He
Shi Liu
ResearchOpen Access04 Jan 2021
Nature Communications

Volume: 12, P: 1-13
Targeting of SLC25A22 boosts the immunotherapeutic response in KRAS-mutant colorectal cancer

KRAS mutations are associated with an immunosuppressive microenvironment in patients with colorectal cancer (CRC). Here the authors show that knockout of SLC25A22, a mitochondrial glutamate carrier, reverts KRAS-mediated immunosuppression in preclinical CRC models, by suppressing CXCL1 production and impairing MDSC recruitment.

Qiming Zhou
Yao Peng
Chi Chun Wong
ResearchOpen Access04 Aug 2023
Nature Communications

Volume: 14, P: 1-17
The cholesterol uptake regulator PCSK9 promotes and is a therapeutic target in APC/KRAS-mutant colorectal cancer

Looking for metabolic-associated vulnerabilities is a promising approach for therapeutic intervention in KRAS-mutant colorectal cancer. Here, the authors show that the cholesterol-uptake regulator PCSK9 drives tumourigenesis and is a therapeutic target in KRASmutant colorectal cancer.

Chi Chun Wong
Jian-Lin Wu
Jun Yu
ResearchOpen Access08 Jul 2022
Nature Communications

Volume: 13, P: 1-15
GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21

How excitatory neurons (EN) acquire senescence is unclear. Here, the authors show that GDF11 in ENs slows EN senescence, brain ageing, cognitive decline and maintains lifespan, revealing a mechanism underlying EN senescence and brain ageing.

Di-Xian Wang
Zhao-Jun Dong
Jing-Wei Zhao
ResearchOpen Access17 Nov 2023
Nature Communications

Volume: 14, P: 1-24
Chemotherapy-induced macrophage CXCL7 expression drives tumor chemoresistance via the STAT1/PHGDH-serine metabolism axis and SAM paracrine feedback to M2 polarization

Shuguang Liu
Hui Gong
Lishan Fang
ResearchOpen Access14 May 2025
Cell Death & Disease

Volume: 16, P: 1-13
Allelic variation of the rice blast resistance gene Pid3 in cultivated rice worldwide

Qiming Lv
Zhiyuan Huang
Lihuang Zhu
ResearchOpen Access04 Sept 2017
Scientific Reports

Volume: 7, P: 1-13
Sex disparities in the association between rare earth elements exposure and genetic mutation frequencies in lung cancer patients

Mengyuan Liu
Jiali Zhang
Niansong Qian
ResearchOpen Access16 Jan 2025
Scientific Reports

Volume: 15, P: 1-12
The evolution and pathogenic mechanisms of the rice sheath blight pathogen

The rice sheath blight pathogen, Rhizoctonia solani, is an important fungal pathogen that can devastate rice and maize crops. Zheng and colleagues sequence and assemble the R. solani AG1 IA genome—the first to be sequenced from the Rhizoctoniagenus—using Illumina sequencing technology.

Aiping Zheng
Runmao Lin
Ping Li
ResearchOpen Access29 Jan 2013
Nature Communications

Volume: 4, P: 1-10
Comprehensive discovery and functional characterization of the noncanonical proteome

Chengyu Shi
Fangzhou Liu
Aifu Lin
ResearchOpen Access10 Jan 2025
Cell Research

Volume: 35, P: 186-204
Anti-oncogene PTPN13 inactivation by hepatitis B virus X protein counteracts IGF2BP1 to promote hepatocellular carcinoma progression

Yongcong Yan
Pinbo Huang
Zhiyu Xiao
ResearchOpen Access13 Oct 2020
Oncogene

Volume: 40, P: 28-45
Toripalimab plus chemotherapy for first line treatment of advanced non-small cell lung cancer (CHOICE-01): final OS and biomarker exploration of a randomized, double-blind, phase 3 trial

Jia Zhong
Kailun Fei
Jie Wang
ResearchOpen Access24 Dec 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-9
First-in-human, phase 1 dose-escalation and dose-expansion study of a RET inhibitor SY-5007 in patients with advanced RET-altered solid tumors

Wei Li
Yongsheng Wang
Caicun Zhou
ResearchOpen Access04 Nov 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-11
Targeting NLRC5 in cardiomyocytes protects postinfarction cardiac injury by enhancing autophagy flux through the CAVIN1/CAV1 axis

NLRC5 facilitates cardiac repair by orchestrating autophagy through CAVIN1 degradation and CAV1/ATG12-5 modulation, positioning NLRC5 as a therapeutic target to mitigate post-MI damage and enhance recovery.

Lingfeng Gu
Sibo Wang
Liansheng Wang
ResearchOpen Access23 Feb 2025
Communications Biology

Volume: 8, P: 1-17
A Quick-responsive DNA Nanotechnology Device for Bio-molecular Homeostasis Regulation

Songlin Wu
Pei Wang
Yi Zhan
ResearchOpen Access10 Aug 2016
Scientific Reports

Volume: 6, P: 1-10
An intelligent humidity sensing system for human behavior recognition

Huabin Yang
Qiming Guo
Haiyang Mao
ResearchOpen Access22 Jan 2025
Microsystems & Nanoengineering

Volume: 11, P: 1-11
Mycobacteriophage SWU1 gp39 can potentiate multiple antibiotics against Mycobacterium via altering the cell wall permeability

Qiming Li
Mingliang Zhou
Jianping Xie
ResearchOpen Access28 Jun 2016
Scientific Reports

Volume: 6, P: 1-14
Proteasome Accessory Factor C (pafC) Is a novel gene Involved in Mycobacterium Intrinsic Resistance to broad-spectrum antibiotics - Fluoroquinolones

Qiming Li
Longxiang Xie
Jianping Xie
ResearchOpen Access03 Jul 2015
Scientific Reports

Volume: 5, P: 1-10
Apatinib Monotherapy for Chemotherapy-Refractory Metastatic Colorectal Cancer: A Multi-centre, Single-Arm, Prospective Study

Fen Wang
Xia Yuan
Shubin Wang
ResearchOpen Access08 Apr 2020
Scientific Reports

Volume: 10, P: 1-13
Helicobacter pylori CagA-mediated ether lipid biosynthesis promotes ferroptosis susceptibility in gastric cancer

Yanmei Peng
Xuetao Lei
Guoxin Li
ResearchOpen Access21 Feb 2024
Experimental & Molecular Medicine

Volume: 56, P: 441-452
An Adaptive Cultural Algorithm with Improved Quantum-behaved Particle Swarm Optimization for Sonar Image Detection

Xingmei Wang
Wenqian Hao
Qiming Li
ResearchOpen Access18 Dec 2017
Scientific Reports

Volume: 7, P: 1-16
Exploring immune related gene signatures and mechanisms linking non alcoholic fatty liver disease to atrial fibrillation through transcriptome data analysis

Keke Wu
Jiayi Zhu
Qiming Liu
ResearchOpen Access16 Oct 2023
Scientific Reports

Volume: 13, P: 1-17
Publisher Correction: Comprehensive discovery and functional characterization of the noncanonical proteome

Chengyu Shi
Fangzhou Liu
Aifu Lin
Amendments and CorrectionsOpen Access10 Mar 2025
Cell Research

Volume: 35, P: 229
METTL1 drives tumor progression of bladder cancer via degrading ATF3 mRNA in an m⁷G-modified miR-760-dependent manner

Haiyun Xie
Mingchao Wang
Gonghui Li
ResearchOpen Access17 Nov 2022
Cell Death Discovery

Volume: 8, P: 1-14
The association between RAPSN methylation in peripheral blood and breast cancer in the Chinese population

Shuifang Lei
Lixi Li
Rongxi Yang
Research06 May 2021
Journal of Human Genetics

Volume: 66, P: 1069-1078
The double inhibition of PDK1 and STAT3-Y705 prevents liver metastasis in colorectal cancer

Wenjuan Qin
Yun Tian
Shaozhong Wei
ResearchOpen Access10 Sept 2019
Scientific Reports

Volume: 9, P: 1-12
Spintronic memristors for computing

Qiming Shao
Zhongrui Wang
Leon O. Chua
ReviewsOpen Access13 May 2025
npj Spintronics

Volume: 3, P: 1-23
Necrostatin-1 treatment inhibits osteocyte necroptosis and trabecular deterioration in ovariectomized rats

Hongwang Cui
Yongjun Zhu
Dianming Jiang
ResearchOpen Access05 Oct 2016
Scientific Reports

Volume: 6, P: 1-13
Probing the Molecular Mechanism of Human Soluble Guanylate Cyclase Activation by NO in vitro and in vivo

Jie Pan
Hong Yuan
Xiangshi Tan
ResearchOpen Access23 Feb 2017
Scientific Reports

Volume: 7, P: 1-14
Mechanical activation of spike fosters SARS-CoV-2 viral infection

Wei Hu
Yong Zhang
Wei Chen
ResearchOpen Access31 Aug 2021
Cell Research

Volume: 31, P: 1047-1060
Regulatory T cells in solid tumor immunotherapy: effect, mechanism and clinical application

Yan Pan
Hanqiong Zhou
Qiming Wang
ReviewsOpen Access11 Apr 2025
Cell Death & Disease

Volume: 16, P: 1-12
How will ai transform urban observing, sensing, imaging, and mapping?

Qihao Weng
Zhiwei Li
Greg Asner
ReviewsOpen Access28 Nov 2024
npj Urban Sustainability

Volume: 4, P: 1-9

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