Transgenerational inheritance (TEI) mechanisms are to some extent conserved across species, but how TEI mediates lipid accumulation is unknown. Here the authors reveal that a network of lipid metabolic genes and chromatin modifications mediated by transcription factors and H3K4 trimethylation work together to achieve multigenerational obesogenic effects in C. elegans fed with a high-fat diet.
- Qin-Li Wan
- Xiao Meng
- Qinghua Zhou
