Nature Search

Retinoic acid normalizes the increased gene transcription rate of TGF–α and EGFR in head and neck cancer cell lines

Jennifer Rubin Grandis
Qing Zeng
David J. Tweardy
Research01 Feb 1996
Nature Medicine

Volume: 2, P: 237-240
RNA structure probing reveals the structural basis of Dicer binding and cleavage

Sequencing methods such as icSHAPE were developed to probe RNA structures transcriptome-wide in cells. To probe intact RNA structures, the authors develop icSHAPE-MaP and apply to Dicer-bound substrates showing that distance measuring is important for Dicer cleavage of pre-miRNAs.

Qing-Jun Luo
Jinsong Zhang
Qiangfeng Cliff Zhang
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-12
Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer

The hydroxylase EgIN2 contributes to triple negative breast cancers. Here, using an enzyme-substrate trapping strategy, the authors identify ASDL as a bona fide substrate of EgIN2 promoting aggressive properties of TNBC via the activation of cMYC signaling.

Giada Zurlo
Xijuan Liu
Qing Zhang
ResearchOpen Access15 Nov 2019
Nature Communications

Volume: 10, P: 1-15
Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosome, but is not linked to non-haematologic cancer risk

Mitchell J. Machiela
Weiyin Zhou
Stephen J. Chanock
ResearchOpen Access13 Jun 2016
Nature Communications

Volume: 7, P: 1-9
Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients

Somatic mutations have been reported in pancreatic adenocarcinomas. Here, Sausen et al. identify further mutations and find that mutations in the chromatin modifying gene, MLL, are associated with increased survival, and that the presence of circulating tumour DNA in the serum of patients is associated with poor survival.

Mark Sausen
Jillian Phallen
Victor E. Velculescu
Research07 Jul 2015
Nature Communications

Volume: 6, P: 1-6
Characterization of core fucosylation via sequential enzymatic treatments of intact glycopeptides and mass spectrometry analysis

Core fucosylation of N-linked glycoproteins has been linked to physiological and pathological processes. Here, the authors develop a mass spectrometry-based method that utilizes Endo F3 followed by PNGase F treatment to quantify site-specific glycoprotein core fucosylation in protein mixtures.

Liwei Cao
T. Mamie Lih
Hui Zhang
ResearchOpen Access07 Jul 2022
Nature Communications

Volume: 13, P: 1-12
Sonication-assisted protein extraction improves proteomic detection of membrane-bound and DNA-binding proteins from tumor tissues

Mass spectrometry-based proteomic studies involve tissue lysis. Herein, we updated our 2018 protocol¹ by implementing a sonication step into urea-based tissue lysis to improve the detection of membrane-bound and DNA-binding proteins.

Qing Kay Li
T. Mamie Lih
Hui Zhang
Protocols17 Feb 2025
Nature Protocols

Volume: 20, P: 2083-2099
Adeno-associated virus-mediated bone morphogenetic protein-7 gene transfer induces C2C12 cell differentiation into osteoblast lineage cells

Min Yang
Qing-jun Ma
Chun-yan Zhou
Research01 Aug 2005
Acta Pharmacologica Sinica

Volume: 26, P: 963-968
Multimodal genomic features predict outcome of immune checkpoint blockade in non-small-cell lung cancer

Anagnostou et al. present an improved predictor of response to immune checkpoint blockade that integrates estimates of tumor mutational burden corrected for tumor purity, RTK genomic alterations, a smoking-related mutational signature and HLA status.

Valsamo Anagnostou
Noushin Niknafs
Victor E. Velculescu
Research13 Jan 2020
Nature Cancer

Volume: 1, P: 99-111
Clonal haematopoiesis and risk of chronic liver disease

A study shows that clonal haematopoiesis of indeterminate potential is associated with an increased risk of chronic liver disease specifically through the promotion of liver inflammation and injury.

Waihay J. Wong
Connor Emdin
Pradeep Natarajan
Research12 Apr 2023
Nature

Volume: 616, P: 747-754
A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium

The Sequencing Quality Control (SEQC) consortium shows that junction discovery and differential gene expression profiling with RNA-seq can be robust but transcript-level and absolute measurements remain challenging.

Zhenqiang Su
Paweł P Łabaj
Leming Shi
Research24 Aug 2014
Nature Biotechnology

Volume: 32, P: 903-914
A novel artemisinin derivative, 3-(12-β-artemisininoxy) phenoxyl succinic acid (SM735), mediates immunosuppressive effects in vitro and in vivo

Wen-liang Zhou
Jin-ming Wu
Jian-ping Zuo
Research01 Nov 2005
Acta Pharmacologica Sinica

Volume: 26, P: 1352-1358
Structure of a eukaryotic SWEET transporter in a homotrimeric complex

The X-ray crystal structure is presented of a seven-transmembrane eukaryotic SWEET glucose transporter, revealing the link between seven-transmembrane eukaryotic SWEETs and their three-transmembrane bacterial homologues and providing insight into eukaryotic sugar transport mechanisms.

Yuyong Tao
Lily S. Cheung
Liang Feng
Research19 Oct 2015
Nature

Volume: 527, P: 259-263
Proteomic characterization of primary and metastatic prostate cancer reveals reduced proteinase activity in aggressive tumors

Qing Kay Li
Jing Chen
Hui Zhang
ResearchOpen Access23 Sept 2021
Scientific Reports

Volume: 11, P: 1-14
The genomic landscape of response to EGFR blockade in colorectal cancer

The effect of somatic genetic changes in colorectal cancer on sensitivity to anti-EGFR antibody therapy is analysed.

Andrea Bertotti
Eniko Papp
Victor E. Velculescu
Research30 Sept 2015
Nature

Volume: 526, P: 263-267
Structures of bacterial homologues of SWEET transporters in two distinct conformations

The X-ray crystal structures of two bacterial homologues of the SWEET sugar transporters are solved in two conformational states, and comparison of these states suggests that transport occurs via a ‘rocker-switch’ mechanism.

Yan Xu
Yuyong Tao
Liang Feng
Research03 Sept 2014
Nature

Volume: 515, P: 448-452
KEAP1 gene mutations and NRF2 activation are common in pulmonary papillary adenocarcinoma

Qing Kay Li
Anju Singh
Edward Gabrielson
Research20 Jan 2011
Journal of Human Genetics

Volume: 56, P: 230-234
Heterogeneous expression of PD-L1 in pulmonary squamous cell carcinoma and adenocarcinoma: implications for assessment by small biopsy

Thomas J Gniadek
Qing Kay Li
Edward Gabrielson
Research06 Jan 2017
Modern Pathology

Volume: 30, P: 530-538
Novel HDAC inhibitor Chidamide synergizes with Rituximab to inhibit diffuse large B-cell lymphoma tumour growth by upregulating CD20

Xu-Wen Guan
Hua-Qing Wang
Feng-Ting Liu
ResearchOpen Access06 Jan 2020
Cell Death & Disease

Volume: 11, P: 1-18
Thyroid MALT lymphoma: self-harm to gain potential T-cell help

Fangtian Wu
Natsuko Watanabe
Ming-Qing Du
ResearchOpen Access21 May 2021
Leukemia

Volume: 35, P: 3497-3508

Search

Retinoic acid normalizes the increased gene transcription rate of TGF–α and EGFR in head and neck cancer cell lines

RNA structure probing reveals the structural basis of Dicer binding and cleavage

Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer

Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients

Characterization of core fucosylation via sequential enzymatic treatments of intact glycopeptides and mass spectrometry analysis

Sonication-assisted protein extraction improves proteomic detection of membrane-bound and DNA-binding proteins from tumor tissues

Adeno-associated virus-mediated bone morphogenetic protein-7 gene transfer induces C2C12 cell differentiation into osteoblast lineage cells

Multimodal genomic features predict outcome of immune checkpoint blockade in non-small-cell lung cancer

Clonal haematopoiesis and risk of chronic liver disease

A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium

A novel artemisinin derivative, 3-(12-β-artemisininoxy) phenoxyl succinic acid (SM735), mediates immunosuppressive effects in vitro and in vivo

Structure of a eukaryotic SWEET transporter in a homotrimeric complex

Proteomic characterization of primary and metastatic prostate cancer reveals reduced proteinase activity in aggressive tumors

The genomic landscape of response to EGFR blockade in colorectal cancer

Structures of bacterial homologues of SWEET transporters in two distinct conformations

KEAP1 gene mutations and NRF2 activation are common in pulmonary papillary adenocarcinoma

Heterogeneous expression of PD-L1 in pulmonary squamous cell carcinoma and adenocarcinoma: implications for assessment by small biopsy

Novel HDAC inhibitor Chidamide synergizes with Rituximab to inhibit diffuse large B-cell lymphoma tumour growth by upregulating CD20

Thyroid MALT lymphoma: self-harm to gain potential T-cell help

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