Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–5 of 5 results
Advanced filters: Author: Qing-tao He Clear advanced filters

  • The interaction between a GPCR, such as the vasopressin receptor-2 (V2R), and arrestin depends on the receptors’ phosphorylation pattern. Here authors use FRET and NMR to analyze the phosphorylation patterns of the V2R-arrestin complex and show that phospho-interactions are the key determinants of selective arrestin conformational states and correlated functions.

    • Qing-Tao He
    • Peng Xiao
    • Xiao Yu
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Characterization of dynamic conformational changes in membrane protein complexes by NMR spectroscopy remains challenging. Here authors report the site-specific incorporation of 4-trimethylsilyl phenylalanine (TMSiPhe) into proteins, which enabled the characterization of multiple conformational states of a phospho-β2 adrenergic receptor/β-arrestin-1 complex in response to different receptor ligands.

    • Qi Liu
    • Qing-tao He
    • Jin-peng Sun
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • The description of the cryo-EM structure of an orphan adhesion GPCR–Gs protein complex in apo state facilitates the screening and identification of potential ligands of ADGRG2.

    • Hui Lin
    • Peng Xiao
    • Xiao Yu
    Research
    Nature Chemical Biology
    Volume: 18, P: 1196-1203

  • NMR and in vitro reconstitution indicate that GPCRs signal through SH3-containing proteins downstream of β-arrestin 1 proline regions and that arrestin allosterically activates downstream kinases by disrupting their autoinhibitory conformation.

    • Fan Yang
    • Peng Xiao
    • Jiangyun Wang
    Research
    Nature Chemical Biology
    Volume: 14, P: 876-886