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Showing 1–4 of 4 results
Advanced filters: Author: Qingan Sun Clear advanced filters

  • The important tuberculosis drug pyrazinamide (PZA) is converted to its active form pyrazinoic acid (POA) in Mycobacterium tuberculosis (Mtb). Here the authors identify the pantothenate biosynthesis pathway enzyme aspartate decarboxylase (PanD) as the target of PZA and determine the POA bound Mtb PanD crystal structure.

    • Qingan Sun
    • Xiaojun Li
    • James C. Sacchettini
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-7

  • Phage lysis requires the enzymatic degradation of the host cell wall by a phage-encoded lysin. Secretory endolysins are inactive at the membrane but active in the cytoplasm, and the signal-anchor-release (SAR) domain is shown to be essential for regulating its effects. The structure of coliphage 21 lysozyme explains how this endolysin is controlled.

    • Qingan Sun
    • Gabriel F Kuty
    • James C Sacchettini
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 1192-1194

  • Lattice dynamics can govern the thermal conductivity solids and understanding the underlying mechanisms may enable enhanced performance of devices via judicious engineering. Here, insight into the anisotropic thermal conductivity of semiconducting α-GaN is gained by measuring the Matryoshka phonon dispersions.

    • Bin Wei
    • Qingan Cai
    • Chen Li
    ResearchOpen Access
    Communications Physics
    Volume: 4, P: 1-9