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Transcriptional profiling of olfactory system development identifies distal antenna as a regulator of subset of neuronal fates

Scott Barish
Qingyun Li
Pelin C. Volkan
ResearchOpen Access19 Jan 2017
Scientific Reports

Volume: 7, P: 1-12
A polyketide-based biosynthetic platform for diols, amino alcohols and hydroxy acids

Medium- and branched-chain diols and amino alcohols are important industrial feedstocks, but they are biosynthetically challenging to produce. Here the authors introduce a modular polyketide synthase platform for the efficient production of these compounds.

Qingyun Dan
Yan Chiu
Jay D. Keasling
ResearchOpen Access11 Feb 2025
Nature Catalysis

Volume: 8, P: 147-161
Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels–Alderase

The complete biosynthesis of the fungal indole alkaloid malbrancheamide, which culminates in an intramolecular [4+2] hetero-Diels–Alder cyclization to produce the bicyclo[2.2.2]diazaoctane scaffold, has now been discovered. Chemical synthesis and protein structural analysis were used to provide mechanistic insight into this enzyme-dependent diastereo- and enantioselective cycloaddition.

Qingyun Dan
Sean A. Newmister
Robert M. Williams
Research23 Sept 2019
Nature Chemistry

Volume: 11, P: 972-980
Bispecific CAR T cell therapy targeting BCMA and CD19 in relapsed/refractory multiple myeloma: a phase I/II trial

CAR-T cell therapies targeting BCMA have shown promising responses in patients with multiple myeloma (MM), however primary resistance and relapse are frequently observed. Here the authors report the results of a phase I//II study of bispecific CAR T-cells targeting BCMA and CD19 in relapsed/refractory MM.

Ming Shi
Jiaojiao Wang
Jiang Cao
ResearchOpen Access20 Apr 2024
Nature Communications

Volume: 15, P: 1-11
Biofilm microenvironment triggered self-enhancing photodynamic immunomodulatory microneedle for diabetic wound therapy

The treatment of diabetic wounds tends to be hindered by complex wound environments, and the critical role of the microenvironment in the chronic diabetic wounds has not been explored for therapeutic development. Here, the authors develop a wound microenvironment-responsive microneedle bandage to achieve self-enhanced, catabolic and dynamic therapy of chronic wounds.

Li Yang
Dan Zhang
Xiaowei Zeng
ResearchOpen Access23 Nov 2023
Nature Communications

Volume: 14, P: 1-17
Biosensor Guided Polyketide Synthases Engineering for Optimization of Domain Exchange Boundaries

Engineering polyketide synthases can be challenging due to the absence of efficient high-throughput methods. Here, the authors used a solubility biosensor to identify stable variants from libraries of modified polyketide synthases.

Elias Englund
Matthias Schmidt
Jay D. Keasling
ResearchOpen Access12 Aug 2023
Nature Communications

Volume: 14, P: 1-12
Complete integration of carbene-transfer chemistry into biosynthesis

The α-diazoester azaserine can be produced by Streptomyces albus engineered with a biosynthetic gene cluster and act as the carbene precursor for coupling with intracellularly produced styrene to generate unnatural amino acids containing a cyclopropyl group.

Jing Huang
Andrew Quest
Jay D. Keasling
Research03 May 2023
Nature

Volume: 617, P: 403-408
Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition

Propionate addition is a common strategy for production of valuable polyketides by supplying the substrate methylmalonyl-CoA in the industrial microbe Corynebacterium glutamicum; however, propionate inhibits C. glutamicum growth, thus hampering polyketide production. In this study, Zhan et al. identify the reasons for propionate-elicited growth inhibition and metabolically engineer C. glutamicum to circumvent this roadblock and increase polyketide production.

Chunjun Zhan
Namil Lee
Jay D. Keasling
Research13 Jul 2023
Nature Metabolism

Volume: 5, P: 1127-1140
Genome-wide association analysis of Vogt-Koyanagi-Harada syndrome identifies two new susceptibility loci at 1p31.2 and 10q21.3

Peizeng Yang, Zhenglin Yang and colleagues report results of a genome-wide association study of Vogt-Koyanagi-Harada syndrome. They confirm strong association with the HLA region and identify two new susceptibility loci, including variants near IL23R.

Shengping Hou
Liping Du
Peizeng Yang
Research01 Sept 2014
Nature Genetics

Volume: 46, P: 1007-1011
Patterns of transcriptional parallelism and variation in the developing olfactory system of Drosophila species

Jia Wern Pan
Qingyun Li
Pelin Cayirlioglu Volkan
ResearchOpen Access18 Aug 2017
Scientific Reports

Volume: 7, P: 1-16

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Transcriptional profiling of olfactory system development identifies distal antenna as a regulator of subset of neuronal fates

A polyketide-based biosynthetic platform for diols, amino alcohols and hydroxy acids

Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels–Alderase

Bispecific CAR T cell therapy targeting BCMA and CD19 in relapsed/refractory multiple myeloma: a phase I/II trial

Biofilm microenvironment triggered self-enhancing photodynamic immunomodulatory microneedle for diabetic wound therapy

Biosensor Guided Polyketide Synthases Engineering for Optimization of Domain Exchange Boundaries

Complete integration of carbene-transfer chemistry into biosynthesis

Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition

Genome-wide association analysis of Vogt-Koyanagi-Harada syndrome identifies two new susceptibility loci at 1p31.2 and 10q21.3

Patterns of transcriptional parallelism and variation in the developing olfactory system of Drosophila species

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