Zhou, Duan, Wang et al. show that d-2-hydroxyglutarate affects mitochondrial health by inhibiting the 3-hydroxypropionate (3-HP) dehydrogenase HPHD-1, leading to a build-up of 3-HP and interference with IMMT-1 (also knowns as MIC60) function in mitochondria structure.
- Junxiang Zhou
- Mei Duan
- Chonglin Yang
