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Advanced filters: Author: Quanzhen Lv Clear advanced filters

Chemoenzymatic synthesis of pentalenolactones via stereoselective Riley oxidation by engineered P450_BM3

Riley oxidation is a powerful chemical tool that traditionally lacks stereocontrol. Here, the authors develop an engineered P450_BM3 enzyme for selective Riley-type desymmetrization of cis-diquinane, enabling the total synthesis of pentalenolactones.

Yaoyao Xu
Kaifeng Zhang
Jian Li
ResearchOpen Access10 Feb 2026
Nature Communications

P: 1-7
Author Correction: The vacuolar fusion regulated by HOPS complex promotes hyphal initiation and penetration in Candida albicans

Yu Liu
Ruina Wang
Lan Yan
Amendments and CorrectionsOpen Access29 May 2024
Nature Communications

Volume: 15, P: 1
Author Correction: The vacuolar fusion regulated by HOPS complex promotes hyphal initiation and penetration in Candida albicans

Yu Liu
Ruina Wang
Lan Yan
Amendments and CorrectionsOpen Access13 Sept 2024
Nature Communications

Volume: 15, P: 1-2
The vacuolar fusion regulated by HOPS complex promotes hyphal initiation and penetration in Candida albicans

The transition between yeast and hyphae is crucial for the pathogenicity of Candida albicans. Here, Liu et al. show that vacuole fusion is active during hyphal extension and that large vacuoles increase the mechanical forces of hyphae penetrating into organs.

Yu Liu
Ruina Wang
Lan Yan
ResearchOpen Access16 May 2024
Nature Communications

Volume: 15, P: 1-20

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Chemoenzymatic synthesis of pentalenolactones via stereoselective Riley oxidation by engineered P450_BM3

Author Correction: The vacuolar fusion regulated by HOPS complex promotes hyphal initiation and penetration in Candida albicans

Author Correction: The vacuolar fusion regulated by HOPS complex promotes hyphal initiation and penetration in Candida albicans

The vacuolar fusion regulated by HOPS complex promotes hyphal initiation and penetration in Candida albicans

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Chemoenzymatic synthesis of pentalenolactones via stereoselective Riley oxidation by engineered P450BM3

Author Correction: The vacuolar fusion regulated by HOPS complex promotes hyphal initiation and penetration in Candida albicans

Author Correction: The vacuolar fusion regulated by HOPS complex promotes hyphal initiation and penetration in Candida albicans

The vacuolar fusion regulated by HOPS complex promotes hyphal initiation and penetration in Candida albicans

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Chemoenzymatic synthesis of pentalenolactones via stereoselective Riley oxidation by engineered P450_BM3