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Showing 1–2 of 2 results
Advanced filters: Author: Quentin I. Churches Clear advanced filters

  • Mobilizing haematopoietic stem cells to the peripheral blood has largely replaced bone marrow transplants as a strategy in the clinic. Here, Cao et al. report the use of an α9β1/α4β1integrin antagonist to induce rapid mobilization of blood stem cells from the bone marrow in a humanized mouse model.

    • Benjamin Cao
    • Zhen Zhang
    • Susan K. Nilsson
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Tackling the loss of expensive cofactors is a key challenge in continuous-flow biocatalysis. This work reports immobilized enzymes with a tethered cofactor that is channelled between a recycling and a catalysis module facilitating total turnover numbers of NAD+ and ATP exceeding 10,000 in biocatalytic flow systems.

    • Carol J. Hartley
    • Charlotte C. Williams
    • Colin Scott
    Research
    Nature Catalysis
    Volume: 2, P: 1006-1015