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Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression

Senescence of mammalian cells is characterized by proliferative arrest and expression of an inflammatory phenotype. Here the authors show the H2A variant H2A.J, found only in mammals, accumulates following persistent DNA damage or natural aging.

Kévin Contrepois
Clément Coudereau
Carl Mann
ResearchOpen Access10 May 2017
Nature Communications

Volume: 8, P: 1-18

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Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression

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