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Showing 1–6 of 6 results
Advanced filters: Author: Régis Pomès Clear advanced filters

  • The α-toxin LqhIII from the deathstalker scorpion inhibits fast inactivation of cardiac NaV1.5 channels. Here authors reveal the cryo-EM structure of LqhIII bound to NaV1.5 which shows that LqhIII traps the gating charges of the S4 segment in a unique intermediate-activated state and explains why LqhIII slows inactivation of NaV channels but does not open them.

    • Daohua Jiang
    • Lige Tonggu
    • William A. Catterall
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • ZnuD is a conserved zinc transporter expressed in several bacterial pathogens with potential as a target against infection. Here the authors demonstrate a requirement for ZnuD in systemic infection by N. meningitidisand define the molecular mechanism of ZnuD-mediated Zinc transport across the bacterial outer membrane.

    • Charles Calmettes
    • Christopher Ing
    • Trevor F. Moraes
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11

  • Store-operated Ca2+channels (CRAC) are involved in several cellular functions. Here the authors identify a hydrophobic gate in the CRAC pore and show that CRAC activation by STIM1 involves rotation of the pore helix that hydrates this region to allow ion passage through the pore.

    • Megumi Yamashita
    • Priscilla S.-W. Yeung
    • Murali Prakriya
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • Crystal structures and molecular dynamics simulations of voltage-gated sodium channels containing mutations that cause hypokalaemic and normokalaemic periodic paralysis indicate the pathogenic mechanisms of these conditions and suggest a target for the design of potential therapeutic and symptomatic drugs.

    • Daohua Jiang
    • Tamer M. Gamal El-Din
    • William A. Catterall
    Research
    Nature
    Volume: 557, P: 590-594