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How daylight saving time shift (DST) affects mortality dynamics on a large population scale remains unknown. Here, the authors examine the impact of DST on all-cause mortality in 16 European countries for the period 1998-2012.

Based on a proteogenomic analysis, Perreault and colleagues report that the majority of predicted tumor antigens originate from unmutated genomic sequences in melanoma and non-small cell lung cancer.

Inertial confinement fusion, based on laser-heating a deuterium–tritium mixture, is one of the approaches towards energy production from fusion reactions. Now, record energy-yield experiments are reported—bringing us closer to ignition conditions.

Here, the authors demonstrate a chip-scale device that realizes a comprehensive set of resonant second order nonlinear processes including optical parametric oscillation with a threshold power of 70 microwatts.

The suppression of edge-localized modes in tokamak plasmas is crucial to prevent them from damaging the walls of the chamber. Now experiments confirm the role that magnetic islands play in suppressing these detrimental modes.

Warmer spring temperatures affect the timing of stem diameter growth of temperate deciduous trees but have little effect on annual growth.

Astrocytes are implicated in the maintenance of the blood-brain barrier (BBB). This study established a microfluidic BBB chip and found that astrocytes may play a role in cerebrovascular dysfunction in people with Parkinson’s disease.

Edge-localized plasma modes in a tokamak can damage its innermost wall. Simulations now show that fast ions can modify the spatio-temporal structure of these modes. These effects need to be considered in the optimization of control techniques.

Measurements of the inelastic cross section of anti-³He allow the estimation of the transparency of the Milky Way to the propagation of these light antinuclei produced in either cosmic-ray collisions or annihilation of dark-matter particles.

Cryptochrome 4 from the night-migratory European robin displays magnetically sensitive photochemistry in vitro, in which four successive flavin–tryptophan radical pairs generate magnetic-field effects and stabilize potential signalling states.

Country difference in macroeconomic cycles-mortality changes relationships has been rarely explored. Here the authors studied the relationship between 2008 recession and daily mortality counts for EU countries and revealed a significant relationship between macroeconomic cycles and mortality trends.

γδ T cells are known to recognize phosphoantigen in the context of butyrophilins (BTN), yet the molecular rules underlying this phenomenon are unclear. Here, the authors demonstrate that a distinct topology of B30.2 and IgV domains within BTN3A complexes promotes antigen sensing and that the juxtamembrane region controls BTN complex formation.

The direct measurement of the QCD dead cone in charm quark fragmentation is reported, using iterative declustering of jets tagged with a fully reconstructed charmed hadron.

Polygenic risk scores for Alzheimer’s disease derived from individuals of European ancestry can show improved performance in multiancestry settings after incorporating genome-wide association summary statistics from diverse populations.

Growing polymer chains are often confined within vesicles in biological systems. Here, the authors study how material properties such as friction, flexibility and thickness affect confined polymer filaments when they grow beyond their equilibrium size, identifying four unique morphologies.

This study unravels an important daytime Cl₂ source in the extra-polar atmosphere and shows that photolysis of particle nitrate at high acidity produced unprecedented levels of Cl₂, boosting the oxidative power and air pollutants like O₃.

Cox and colleagues develop PXS-5505, a first-in-class selective pan-lysyl oxidase inhibitor and show that it reduces chemotherapy-induced desmoplasia and stiffness, thereby improving chemotherapy response and survival in pancreatic cancer models.

Endothelial cells from vascular-dependent central nervous system (CNS) diseases reveal reactivated fetal pathways, display common hallmarks of disease — including a partial loss of arteriovenous specification and CNS-specific properties as well as an upregulation of MHC class II receptors — and play a key role in the human brain neurovascular unit across development, adulthood and disease.

Phage capsids modified with spatially defined patterns of host cell ligands can act as multivalent binders for the influenza A virus to prevent viral infection.

Biallelic mutations in the sorbitol dehydrogenase gene SORD are identified as a common cause of hereditary neuropathy. Functional studies suggest that SORD deficiency may be treatable with aldose reductase inhibitors.

Correlations in momentum space between hadrons created by ultrarelativistic proton–proton collisions at the CERN Large Hadron Collider provide insights into the strong interaction, particularly the short-range dynamics of hyperons—baryons that contain strange quarks.

The distribution and organisation of matrix molecules in the tumour stroma help shape solid tumour progression. Here they perform temporal proteomic profiling of the matrisome during breast cancer progression and show that collagen XII secreted from CAFs provides a pro-invasive microenvironment.

Attractions between heterochromatic regions are essential for phase separation of the active and inactive genome in inverted and conventional nuclei, whereas chromatin–lamina interactions are necessary to build the conventional genomic architecture from these segregated phases.

Packing nanoparticles into ordered superstructures finds applications in photonic materials, but fabrication over large scales is challenging. Zhao et al. show a roll-to-roll approach to prepare flexible films of ordered polymer nanoparticles via an oscillatory shear-induced structural transition.

A combination of genome-wide CRISPR screens in target cancer cells identifies pathways that regulate γδ T cell killing and BTN3A cell surface expression.

An antimatter hypernucleus formed by an anti-lambda hadron, an antiproton and two antineutrons was observed through its two-body decay after production in ultrarelativistic heavy-ion collisions.

Nanoparticles have recently received attention in radiation therapy since they can act as radioenhancers. In this article, the authors report on the dose enhancement capabilities of a series of nanoparticles based on their metal core composition and beam characteristics, obtaining designing criteria for their optimal performance in specific radiotreatments.

At the Relativistic Heavy Ion Collider, observations of two meson species produced by heavy-ion collisions, ϕ and K^*0, show surprising patterns of global spin alignment, being unexpectedly large and consistent with zero, respectively.

The development of dental calculi involves bacteria in local mature biofilms converting the DNA in neutrophil extracellular traps from being degradable by the enzyme DNase I to being degradation resistant.