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Observations from an underwater glider show that meltwater from giant icebergs increases ocean stratification near the surface and mixing below, potentially impacting biological productivity.

Authors show that Antarctic glaciers deliver high particle loads to the ocean, rich in iron that is potential food for marine algae. Microscopy techniques reveal this iron interacts with carbon. Ocean tracers show this glacial iron reaches far offshore.

Observations from a remotely operated underwater vehicle reveal crevasse refreezing and the fine-scale variability in ice and ocean structure at the Kamb Ice Stream grounding line in West Antarctica.

Interactions between meltwater flow and ice shelf basal channels are studied using a 3D boundary current model. Deep channels are found to significantly enhance channelized basal melting, meltwater channeling, and warming and salinization of channel flow.

This analysis comprehensively compares methods for gene regulatory network inference submitted through the DREAM5 challenge. It demonstrates that integration of predictions from multiple methods shows the most robust performance across data sets.

Protein/protein interaction (PPI) interfaces have emerged as drug targets to develop medications with less side effects. Here, Dvorak et al. show that small molecule targeting of PPIs in the brain is an approach for psychiatric drug discovery.

The central densities of protons and neutrons in stable atomic nuclei are saturated. More exotic nuclei — with imbalanced proton and neutron numbers — may have depleted central densities. Experiments now suggest such depletion for the ³⁴Si nucleus.

Methods for transition-metal-catalysed enantioselective C(sp³)–S bond construction are underdeveloped. Now, by taking advantage of the biomimetic radical homolytic substitution manifold, the copper-catalysed enantioconvergent C(sp³)–S cross-coupling of racemic secondary and tertiary alkyl halides with highly transformable sulfur nucleophiles has been realized. This reaction provides access to an array of α-chiral alkyl organosulfur compounds.

A study of dependencies associated with cancer-causing mutations has identified a small molecule that binds to SHOC2 and inhibits RAS signalling in cells carrying NRAS Q61 mutations, a common oncogenic driver in melanoma.

So far most of the de novo designed proteins are for single states only. Here, the authors present the de novo design and crystal structure determination of a coiled-coil peptide that assembles into multiple, distinct conformational states under the same conditions and further characterise its properties with biophysical experiments, NMR and MD simulations.

Gain of function mutant CaV1.2 channels drive life-threatening hypoglycemia in the multisystem disorder Timothy syndrome, but the underlying mechanisms are unknown. Here the authors show the mutant channels have adverse effects on counterregulatory hormones and CNS control of glucose homeostasis.

Genome-wide association analyses of 41,917 bipolar disorder cases and 371,549 controls of European ancestry provide new insights into the etiology of this disorder and identify novel therapeutic leads and potential opportunities for drug repurposing.

Enterohaemorrhagic Escherichia coli(EHEC) is an important foodborne pathogen that colonizes the large intestine. Here, the authors identify a signalling pathway that controls EHEC adherence to host cells in response to variations in biotin levels, ensuring selective colonization of the large intestine.

Thwaites Eastern Ice Shelf observations from a new underwater vehicle show that high melt rates occur where ice is sharply sloped at the ocean interface, with lower melt where the ice is comparatively flat.

Osteoarthritis can be caused by multiple biological mechanisms but the drivers of disease risk are not well understood. Here, the authors use data from UK Biobank in machine learning models to identify clinical and biological markers associated with development of osteoarthritis and identify sub-groups with different risk profiles.

Mosaic copy number gains arising from an extra parentally derived chromosome 1q allele are found in brain tissue from five individuals with focal epilepsy. These copy number gains are strongly enriched in astrocytes, indicating somatic rescue in other tissues during development.

Genome-wide analysis identifies 30 loci associated with bipolar disorder, allowing for comparisons of shared genes and pathways with other psychiatric disorders, including schizophrenia and depression.

Alzheimer’s Disease (AD) is commonly preceded by a prodromal period. Here, the authors report the presence of large plasma Aβ aggregates from patients with mild cognitive impairment, which associate with low level AD-like brain pathology as observed by 11C-PiB PET and 18F-FTP PET and lowered CD18-rich monocytes.

This study provides evidence for long-term effects of volcanic emissions of large quantities of gaseous mercury (Hg) and plant mutagenesis by recording high abundances of malformed fern spores across the Triassic-Jurassic boundary and Early Jurassic.

Meta-analysis of 36,760 cases and 375,188 controls identifies 54 loci associated with susceptibility to cutaneous melanoma. Further analysis combining nevus count and hair color GWAS results provide insights into the genetic architecture of melanoma.

A lack of annually resolved climate records from the marine archive limits our understanding of oceanic processes. Here, the authors present a millennial-length, annually-resolved and absolutely-dated marine δ¹⁸O record from the shells of marine bivalves and offer insight into North Atlantic climate dynamics.

Theory predicts a deficit of super-Earth sized planets, which orbit close to their host star. Here, Lundkvist et al. use data from the NASA Kepler mission to show that this deficit is also seen in observations, thereby providing new insight into exoplanetary systems.

Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse transcriptase (TERT) expression via ZNF148.

Treatment of HIV-1 infected patients with latency-reversing agents (LRA) induces transcription of proviruses in CD4 T cells. Using single-genome sequencing, the authors show that the LRA-induced CD4 T cell-associated HIV RNA is genetically diverse and contains a high proportion of defective RNA.

Multiple myeloma is a cancer of the plasma cells, and the complete aetiology of the disease is still unclear. Here the authors perform an additional GWAS analysis followed by a meta-analysis with existing GWAS and replication genotyping and identify 6 novel risk loci and utilise gene expression, epigenetic profiling and in situ Hi-C data to further our understanding of MM susceptibility.

An ambitious study has used more than 10,000 datasets to examine how the phenological characteristics—such as the timing of reproduction—of various taxa alter in response to climate change, and suggests that differing levels of climate sensitivity could lead to the desynchronization of seasonal events over time.

The use of a high-affinity VHL ligand allows the development of chimeric molecules that promote the association of ERRα or RIPK2 with the VHL E3 ubiquitin ligase complex, resulting in protein degradation.

Matthew Law, Mark Iles and colleagues report the results of a large-scale genome-wide meta-analysis of cutaneous malignant melanoma. They confirm previously reported association signals and identify five new susceptibility loci, with associated variants mapping within putative melanocyte regulatory elements.

The causes of Mid-Pleistocene Transition global cooling 1 million years ago are still unknown. Here, the authors find the subarctic North Pacific became stratified during these glaciations due to closure of the Bering Strait, which would have removed CO₂ from the atmosphere and caused global cooling.

Whole-genome and targeted sequencing of multiple sections of each of 50 tumors reveals varying degrees of subclonal diversification and genomic heterogeneity.

Plasmacytoid dendritic cells (pDC) are an important regulator of immune responses. Here the authors show that pDC precursors, similar to peripheral blood-derived pDCs, can be differentiated from human CD34⁺ hematopoietic stem and progenitor cells, with type I/II IFN priming being required for their functional maturation and differentiation.