Nature Search

A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma

Choi et al. highlight the centrality of glycolysis in squamous cell carcinoma, revealing the glycolysis-dampening tumour suppressor role of Sirt6, and identifying a subset of highly glycolytic tumour-propagating cells with elevated antioxidant capacity.

Jee-Eun Choi
Carlos Sebastian
Raul Mostoslavsky
Research22 Feb 2021
Nature Metabolism

Volume: 3, P: 182-195
The glutathione S-transferase Gstt1 drives survival and dissemination in metastases

With a shRNA targeted screen, Ferrer, Cho, Boon et al. identify a role for Gstt1 in enhancing epithelial–mesenchymal transition and disseminated tumour cell features in a subset of slow-cycling cells, thereby facilitating metastatic progression.

Christina M. Ferrer
Hyo Min Cho
Raul Mostoslavsky
Research11 Jun 2024
Nature Cell Biology

Volume: 26, P: 975-990
Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and solid tumor microenvironment

The emergency of a high frequency of early memory T cells has been associated with clinical success of CAR T cell therapy. Here the authors show that target cancer cells stressed by disulfiram/copper complexes and ionizing radiation favour the reprogramming of CAR T cells that acquire memory-like characteristics, associated with prolonged anti-tumor response in preclinical solid tumor models.

Yufeng Wang
David L. Drum
Xinhui Wang
ResearchOpen Access15 Sept 2023
Nature Communications

Volume: 14, P: 1-17
Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells

The beneficial effects of exercise on cardiovascular disease are linked to decreased inflammation through crosstalk between adipose tissue and hematopoietic progenitor cells in the bone marrow.

Vanessa Frodermann
David Rohde
Matthias Nahrendorf
Research07 Nov 2019
Nature Medicine

Volume: 25, P: 1761-1771
A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine

Metabolic reprogramming upon SIRT6 loss induces tumour formation in the intestine but the mechanism is unclear. Here, the authors show that loss of SIRT6 leads to the expansion of epithelial cells with high pyruvate dehydrogenase kinase activity resulting in enhanced stem cell activity and tumour-initiating potential

Carlos Sebastian
Christina Ferrer
Raul Mostoslavsky
ResearchOpen Access21 Mar 2022
Nature Communications

Volume: 13, P: 1-13
DNA replication fork speed underlies cell fate changes and promotes reprogramming

Totipotent cells in mouse embryos and 2-cell-like cells have slow DNA replication fork speed. Perturbations that slow replication fork speed promote 2-cell-like cell emergence and improve somatic cell nuclear transfer reprogramming and formation of induced pluripotent stem cell colonies.

Tsunetoshi Nakatani
Jiangwei Lin
Maria-Elena Torres-Padilla
ResearchOpen Access07 Mar 2022
Nature Genetics

Volume: 54, P: 318-327
Effects of extensive protein hydrolysate in supporting intestinal barrier function in vitro

Valentina Bozzetti
Rachel Brosnan
Alessio Fasano
ResearchOpen Access21 Jan 2026
Pediatric Research

P: 1-10
IRF3 and type I interferons fuel a fatal response to myocardial infarction

The massive cell death that occurs during myocardial infarction releases self-DNA and triggers an interferon response in infiltrating leukocytes via a cGAS–STING–IRF3 pathway. Interference with this response—either by genetic disruption of the pathway or antibody blockade of the type I interferon receptor—is beneficial in mice subjected to myocardial infarction.

Kevin R King
Aaron D Aguirre
Ralph Weissleder
Research06 Nov 2017
Nature Medicine

Volume: 23, P: 1481-1487
Synergistic activity and heterogeneous acquired resistance of combined MDM2 and MEK inhibition in KRAS mutant cancers

A N Hata
S Rowley
J A Engelman
Research07 Aug 2017
Oncogene

Volume: 36, P: 6581-6591

Search

Filter By:

Search

Quick links