Belorusova et al. use HDX-MS to identify specific regions of liver X receptors LXRα/β which differentially correlate with anti-atherogenic and lipogenic activities of ligands. They also show that their differential stabilisation can allow the separation of beneficial anti-atherogenic from adverse lipogenic effects and thus help in the design of drugs with improved therapeutic indexes.
- Anna Y. Belorusova
- Emma Evertsson
- Eva-Lotte Lindstedt
