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Showing 1–50 of 52 results

Advanced filters: Author: R Lupu Clear advanced filters

Direct specification of lymphatic endothelium from mesenchymal progenitors

Lupu, Grainger, Kirschnick et al. show that, contrary to prevailing belief, the initial specification of mammalian lymphatic endothelial cells primarily occurs from previously unidentified mesenchymal angioblasts rather than from venous endothelium.

Irina-Elena Lupu
David E. Grainger
Oliver A. Stone
ResearchOpen Access02 Jan 2025
Nature Cardiovascular Research

Volume: 4, P: 45-63
Interactions of Protein (Antibodies) with the Deoxyribonucleic Acid Molecule

A. M. POVERENNY
A. S. SAIENKO
VALENTINA A. NASONOVA
Research17 Sept 1966
Nature

Volume: 211, P: 1297-1298
Bioassay of Sheep Anterior Pituitary Glands

D. R. LAMOND
H. M. RADFORD
A. L. WALLACE
Research06 Jun 1959
Nature

Volume: 183, P: 1597-1598
α-Hydroxybutyric Dehydrogenase Activity of Human Vascular Tissue

R. SANWALD
J. E. KIRK
Research26 Feb 1966
Nature

Volume: 209, P: 912-913
Water column dissolution of aragonite in the Pacific Ocean

Robert H. Byrne
James G. Acker
Marion H. Cates
Research22 Nov 1984
Nature

Volume: 312, P: 321-326
Neuronal inhibition by the peptide FMRFamide involves opening of S K⁺ channels

F. Belardetti
E. R. Kandel
S. A. Siegelbaum
Research08 Jan 1987
Nature

Volume: 325, P: 153-156
Amniotic Fluid Concentrations of Renin and Aldosterone during Development in the Fetal Sheep

Sharon R Siegel
Research01 Nov 1981
Pediatric Research

Volume: 15, P: 1419-1421
Photocatalytic degradation of azithromycin and ceftriaxone using synthesized Ag/g-C₃N₄/Fe₃O₄ nanocomposites in aqueous solution

Amirali Emadi Khyave
Roya Mafigholami
Lida Salimi
ResearchOpen Access28 May 2025
Scientific Reports

Volume: 15, P: 1-23
Prognosis based on primary breast carcinoma instead of pathological nodal status

S Ménard
R Bufalino
MI Colnaghi
Research01 Oct 1994
British Journal of Cancer

Volume: 70, P: 709-712
erbB-2 antisense oligonucleotides inhibit the proliferation of breast carcinoma cells with erbB-2 oncogene amplification

R Colomer
R Lupu
EP Gelmann
Research01 Nov 1994
British Journal of Cancer

Volume: 70, P: 819-825
Ontogeny of the Renin-Angiotensin-Aldosterone System in the Fetal and Newborn Lamb

Sharon R Siegel
Delbert A Fisher
Research01 Feb 1980
Pediatric Research

Volume: 14, P: 99-102
c-erbB3 and c-erbB4 expression is a feature of the endocrine responsive phenotype in clinical breast cancer

J M Knowlden
J M W Gee
R I Nicholson
Research14 Oct 1998
Oncogene

Volume: 17, P: 1949-1957
A reflective, metal-rich atmosphere for GJ 1214b from its JWST phase curve

A spectroscopic thermal phase curve of GJ 1214b obtained with the JWST in the mid-infrared is reported and a planet with a high metallicity atmosphere blanketed by thick and reflective clouds or haze is found.

Eliza M.-R. Kempton
Michael Zhang
Peter McGill
Research10 May 2023
Nature

Volume: 620, P: 67-71
A dust-obscured massive maximum-starburst galaxy at a redshift of 6.34

A massive starburst galaxy with 100 billion solar masses of gas is identified at a redshift of 6.34; a ‘maximum starburst’ converts the gas into stars at a rate more than 2,000 times that of the Milky Way.

Dominik A. Riechers
C. M. Bradford
J. Zmuidzinas
Research17 Apr 2013
Nature

Volume: 496, P: 329-333
MiCASA is a new method for quantifying cellular organization

There are few methods available that can quantify relationships between cell types in tissue images. Here the authors present a quantitative method to evaluate cellular organization, validated in the mouse thymus and spinal cord, called Multitaper Circularly Averaged Spectral Analysis (MiCASA).

Andrew Sornborger
Jie Li
Nancy R. Manley
ResearchOpen Access30 May 2017
Nature Communications

Volume: 8, P: 1-10
Laminin activates the p185^HER2 oncoprotein and mediates growth inhibition of breast carcinoma cells

E Tagliabue
E Ardini
S Ménard
Research01 Nov 1996
British Journal of Cancer

Volume: 74, P: 1427-1433
Oestrogen and growth factor cross-talk and endocrine insensitivity and acquired resistance in breast cancer

R I Nicholson
J M W Gee
ReviewsOpen Access07 Jan 2000
British Journal of Cancer

Volume: 82, P: 501-513
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration

Bert Oosthuyse
Lieve Moons
Peter Carmeliet
Research01 Jun 2001
Nature Genetics

Volume: 28, P: 131-138
The root meristem is shaped by brassinosteroid control of cell geometry

What is the effect of hormones on cell shape and growth? In this study, morphometric, genetic and computer modelling analyses are combined to show how brassinosteroids control overall root meristem geometry and development.

Y. Fridman
S. Strauss
S. Savaldi-Goldstein
ResearchOpen Access15 Nov 2021
Nature Plants

Volume: 7, P: 1475-1484
Quantum advantage in postselected metrology

In quantum metrology (as well as computing) it is not easy to pinpoint the specific source of quantum advantage. Here, the authors reveal a link between postselection and the unusually high rates of information per final measurement in general quantum parameter-estimation scenarios.

David R. M. Arvidsson-Shukur
Nicole Yunger Halpern
Seth Lloyd
ResearchOpen Access29 Jul 2020
Nature Communications

Volume: 11, P: 1-7
Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells

Javier A Menendez
Bharvi P Oza
Ruth Lupu
Research19 Apr 2004
Oncogene

Volume: 23, P: 4945-4958
Animal models to study cardiac regeneration

Some species have a greater capacity for cardiac regeneration than others. In this Review, Weinberger and Riley summarize the diverse array of vertebrates that have been studied for their cardiac regenerative potential and the core mechanisms that regulate cardiac regeneration across vertebrate species.

Michael Weinberger
Paul R. Riley
Reviews14 Aug 2023
Nature Reviews Cardiology

Volume: 21, P: 89-105
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

Fatty acid synthase (FASN) catalyses the synthesis of fatty acids, and this synthetic pathway is upregulated in many tumours. How might FASN and increased lipogenesis be involved in cancer, and is FASN a valid therapeutic target?

Javier A. Menendez
Ruth Lupu
Reviews01 Oct 2007
Nature Reviews Cancer

Volume: 7, P: 763-777
Anti-Her-2/neu antibody induces apoptosis in Her-2/neu overexpressing breast cancer cells independently from p53 status

T Brodowicz
D Kandioler
C C Zielinski
ResearchOpen Access27 Nov 2001
British Journal of Cancer

Volume: 85, P: 1764-1770
Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation

R K Schmidt-Ullrich
R B Mikkelsen
P B Chen
Research04 Sept 1997
Oncogene

Volume: 15, P: 1191-1197
Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer

Radionuclides that emit alpha particles (charged helium nuclei) are currently used clinically to treat cancers including prostate cancer. Here, the authors combine a humanized antibody to an alpha particle emitter, specifically to target a downstream effector of the androgen receptor and create a feed forward loop that increases the therapeutic efficacy.

Michael R. McDevitt
Daniel L. J. Thorek
David Ulmert
ResearchOpen Access24 Apr 2018
Nature Communications

Volume: 9, P: 1-11
Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal

Genomic instability has been implicated in tumour development. Here, a new mouse model of Kras-driven lung tumours has been developed, in which genomic instability is caused by overexpression of the mitotic checkpoint protein Mad2. In this model, inhibiting Kras leads to tumour regression, as shown previously. But tumours recur at a much higher rate.

Rocio Sotillo
Juan-Manuel Schvartzman
Robert Benezra
Research21 Feb 2010
Nature

Volume: 464, P: 436-440
An ultrahot gas-giant exoplanet with a stratosphere

Observations of the gas-giant exoplanet WASP-121b reveal near-infrared emission lines of water, suggesting that the planet has a stratosphere—a layer in the upper atmosphere where temperature increases with altitude.

Thomas M. Evans
David K. Sing
Roxana Lupu
Research03 Aug 2017
Nature

Volume: 548, P: 58-61
Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2

A transmembrane O-glycoprotein podoplanin (PDPN) expressed on fibroblastic reticular cells is the activating ligand for platelet receptor CLEC-2; this interaction leads to perivenular release of sphingosine-1-phosphate and expression of VE-cadherin on high endothelial venules, a key process for the maintenance of vascular integrity in lymph nodes.

Brett H. Herzog
Jianxin Fu
Lijun Xia
Research01 Sept 2013
Nature

Volume: 502, P: 105-109
The 121 amino acid isoform of vascular endothelial growth factor is more strongly tumorigenic than other splice variants in vivo

H-T Zhang
P A E Scott
R Bicknell
ResearchOpen Access06 Jun 2000
British Journal of Cancer

Volume: 83, P: 63-68
Endogenous myoglobin in human breast cancer is a hallmark of luminal cancer phenotype

G Kristiansen
M Rose
E Dahl
ResearchOpen Access08 Jun 2010
British Journal of Cancer

Volume: 102, P: 1736-1745
γ-Heregulin has no biological significance in primary breast cancer

E A Sánchez-Valdivieso
J J Cruz
R González-Sarmiento
CorrespondenceOpen Access16 Apr 2002
British Journal of Cancer

Volume: 86, P: 1362-1363
SupraMolecular BioVectors (SMBV) improve antisense inhibition of erbB-2 expression

C Allal
S Sixou
G Favre
Research01 May 1998
British Journal of Cancer

Volume: 77, P: 1448-1453
Choroidal endothelial junctions in primates

A R Nagy
T E Ogden
Research01 Mar 1990
Eye

Volume: 4, P: 290-302
A unique hot Jupiter spectral sequence with evidence for compositional diversity

A population study of near-infrared spectra of 19 hot giant planets shows a correlation between the strength of the 1.4 μm water band and temperature, which is broadly regulated by irradiation. However, the observed scatter around the mean is indicative of the effect of individual planetary formation pathways on the composition.

Megan Mansfield
Michael R. Line
Gael M. Roudier
Research21 Oct 2021
Nature Astronomy

Volume: 5, P: 1224-1232
Peripheral decarboxylase inhibitors paradoxically induce aromatic L-amino acid decarboxylase

Anouke van Rumund
Lukas Pavelka
Marcel M. Verbeek
ResearchOpen Access19 Mar 2021
npj Parkinson's Disease

Volume: 7, P: 1-5
Cold plasma selectivity and the possibility of a paradigm shift in cancer therapy

M Keidar
R Walk
B Trink
ResearchOpen Access06 Oct 2011
British Journal of Cancer

Volume: 105, P: 1295-1301
A novel CYR61-triggered ‘CYR61-α_vβ₃ integrin loop’ regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway

Javier A Menendez
Luciano Vellon
Ruth Lupu
Research13 Dec 2004
Oncogene

Volume: 24, P: 761-779
The autophagy conundrum in cancer: influence of tumorigenic metabolic reprogramming

C H Eng
R T Abraham
Reviews13 Jun 2011
Oncogene

Volume: 30, P: 4687-4696
PTEN action in leukaemia dictated by the tissue microenvironment

A mouse model of T-cell leukaemia is used to test whether PTEN loss is required for tumour maintenance as well as initiation; although it had little effect on tumour load in haematopoietic organs, PTEN reactivation reduced the CCR9-dependent tumour dissemination to the intestine that was amplified on PTEN loss, exposing the importance of tumour microenvironment in PTEN-deficient settings.

Cornelius Miething
Claudio Scuoppo
Scott W. Lowe
Research04 May 2014
Nature

Volume: 510, P: 402-406
Angiogenesis is an independent prognostic factor in malignant mesothelioma

J G Edwards
G Cox
K J O'Byrne
ResearchOpen Access11 Sept 2001
British Journal of Cancer

Volume: 85, P: 863-868
Online hate network spreads malicious COVID-19 content outside the control of individual social media platforms

N. Velásquez
R. Leahy
N. F. Johnson
ResearchOpen Access15 Jun 2021
Scientific Reports

Volume: 11, P: 1-8
Tissue-selective expression of dominant-negative proteins for the regulation of vascular smooth muscle cell proliferation

J F Schmitt
M-C Keogh
N R Lemoine
Research25 Jun 1999
Gene Therapy

Volume: 6, P: 1184-1191
Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted

S Langbein
M Zerilli
J F Coy
ResearchOpen Access07 Feb 2006
British Journal of Cancer

Volume: 94, P: 578-585
Hidden order across online extremist movements can be disrupted by nudging collective chemistry

N. Velásquez
P. Manrique
N. F. Johnson
ResearchOpen Access19 May 2021
Scientific Reports

Volume: 11, P: 1-11
Fatty acid synthase regulates estrogen receptor-α signaling in breast cancer cells

J A Menendez
R Lupu
ResearchOpen Access27 Feb 2017
Oncogenesis

Volume: 6, P: e299
The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas

F Seguin
M A Carvalho
E Graner
ResearchOpen Access14 Aug 2012
British Journal of Cancer

Volume: 107, P: 977-987
The Rafts of the Medusa: cholesterol targeting in cancer therapy

M R Freeman
D Di Vizio
K R Solomon
Comments & Opinion03 May 2010
Oncogene

Volume: 29, P: 3745-3747
Clinical trial design during and beyond the pandemic: the I-SPY COVID trial

Carolyn S. Calfee
Kathleen D. Liu
Lindsie L. Boerger
Correspondence20 Jan 2022
Nature Medicine

Volume: 28, P: 9-11
Age at onset as stratifier in idiopathic Parkinson’s disease – effect of ageing and polygenic risk score on clinical phenotypes

L. Pavelka
A. Rauschenberger
Paul Wilmes
ResearchOpen Access09 Aug 2022
npj Parkinson's Disease

Volume: 8, P: 1-10

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