Nature Search

The 201 Trial: a placebo-controlled randomized phase 2 study of safety and tolerance of the c-Abl kinase inhibitor risvodetinib in untreated Parkinson’s disease

Werner et al. present the results of the 201 Trial, a 12-week randomized, double-blind placebo-controlled phase 2a study of risvodetinib, in patients with early untreated Parkinson’s disease. Risvodetinib was found to be safe and well tolerated.

M. H. Werner
A. McGarry
C. W. Olanow
ResearchOpen Access20 Feb 2026
Nature Aging

P: 1-10
Antibody-forming cells in human colostrum after oral immunisation

R. M. GOLDBLUM
S. AHLSTEDT
A. SOHL-ÅKERLUND
Research30 Oct 1975
Nature

Volume: 257, P: 797-799
High-temperature ²⁰⁵Tl decay clarifies ²⁰⁵Pb dating in early Solar System

Measurement of the bound-state β⁻ decay of ²⁰⁵Tl⁸¹⁺ gives a new, longer half-life, allowing for the calculation of accurate stellar ²⁰⁵Pb yields and the isolation time of the early Solar System.

Guy Leckenby
Ragandeep Singh Sidhu
Jianwei Zhao
ResearchOpen Access13 Nov 2024
Nature

Volume: 635, P: 321-326
Structural basis of TRPV1 modulation by endogenous bioactive lipids

Using cryo-EM, the authors elucidate the mechanisms of TRPV1 regulation by bioactive lipids, namely phosphoinositides and the inflammatory lipid lysophosphatidic acid.

William R. Arnold
Adamo Mancino
Yifan Cheng
ResearchOpen Access02 May 2024
Nature Structural & Molecular Biology

Volume: 31, P: 1377-1385
The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes

HDX–MS analysis reveals the SARS-CoV-2 spike ectodomain reversibly samples an open-trimer conformation that reveals epitopes for a pan-coronavirus antibody; interconversion with the prefusion conformation is modulated by temperature, ACE2 receptor binding, and sequence variants.

Shawn M. Costello
Sophie R. Shoemaker
Susan Marqusee
Research02 Mar 2022
Nature Structural & Molecular Biology

Volume: 29, P: 229-238
Nutritional quality and labelling of ready-to-eat breakfast cereals: the contribution of the French observatory of food quality

R Goglia
M Spiteri
J L Volatier
Research03 Nov 2010
European Journal of Clinical Nutrition

Volume: 64, P: S20-S25
In vitro and ex vivo activity of the fluoroquinolone DC-159a against mycobacteria

Belén R. Imperiale
María B. Mancino
Nora S. Morcillo
Research04 Mar 2024
The Journal of Antibiotics

Volume: 77, P: 306-314
Detailed deletion mapping of chromosome band 14q32 in human neuroblastoma defines a 1.1-Mb region of common allelic loss

M Hoshi
N Otagiri
A Horii
ResearchOpen Access04 May 2000
British Journal of Cancer

Volume: 82, P: 1801-1807
Age-specific changes in the prevalence and management of optically correctable visual impairment between 1988 and 2000: the Ponza Eye Study

C Cedrone
F Ricci
F Culasso
Research18 Apr 2008
Eye

Volume: 23, P: 522-529
Cytolytic P2X purinoceptors

Francesco Di Virgilio
Paola Chiozzi
Olavio R Baricordi
Reviews07 Apr 1998
Cell Death & Differentiation

Volume: 5, P: 191-199
FTO predicts weight regain in the Look AHEAD clinical trial

J M McCaffery
G D Papandonatos
R R Wing
Research03 Apr 2013
International Journal of Obesity

Volume: 37, P: 1545-1552
Identification of 217 unreported mutations in the F8 gene in a group of 1,410 unselected Italian patients with hemophilia A

R. Santacroce
M. Acquila
M. Margaglione
Research01 Mar 2008
Journal of Human Genetics

Volume: 53, P: 275-284
Neuroprotective agents in the management of glaucoma

C. Nucci
A. Martucci
R. Mancino
ReviewsOpen Access23 Feb 2018
Eye

Volume: 32, P: 938-945

Search

The 201 Trial: a placebo-controlled randomized phase 2 study of safety and tolerance of the c-Abl kinase inhibitor risvodetinib in untreated Parkinson’s disease

Antibody-forming cells in human colostrum after oral immunisation

High-temperature ²⁰⁵Tl decay clarifies ²⁰⁵Pb dating in early Solar System

Structural basis of TRPV1 modulation by endogenous bioactive lipids

The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes

Nutritional quality and labelling of ready-to-eat breakfast cereals: the contribution of the French observatory of food quality

In vitro and ex vivo activity of the fluoroquinolone DC-159a against mycobacteria

Detailed deletion mapping of chromosome band 14q32 in human neuroblastoma defines a 1.1-Mb region of common allelic loss

Age-specific changes in the prevalence and management of optically correctable visual impairment between 1988 and 2000: the Ponza Eye Study

Cytolytic P2X purinoceptors

FTO predicts weight regain in the Look AHEAD clinical trial

Identification of 217 unreported mutations in the F8 gene in a group of 1,410 unselected Italian patients with hemophilia A

Neuroprotective agents in the management of glaucoma

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