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Showing 1–6 of 6 results
Advanced filters: Author: R Swarte Clear advanced filters
  • Here, Swarte et al. use metagenomics to investigate the association between the gut microbiome and Health-Related Quality of Life (HRQoL) in kidney transplant recipients, showing evidence for the association of multiple taxonomic, metabolic and neuroactive pathways (gut brain modules) with lower HRQoL, together suggesting potential modifiable gut microbial factors to improve HRQoL.

    • J. Casper Swarte
    • Tim J. Knobbe
    • Rinse K. Weersma
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11
  • Swarte, Zhang and colleagues review the microbiome in solid-organ transplantation and allogeneic haematopoietic-stem-cell transplantation recipients, considering the effects of the intestinal environment, interactions between the microbiota and immunosuppressive drugs, and effects of dysbiosis on transplantation outcomes. The potential of microbiome-targeted interventions to improve transplantation outcomes is also discussed.

    • J. Casper Swarte
    • Shuyan Zhang
    • Rinse K. Weersma
    Reviews
    Nature Reviews Microbiology
    P: 1-17
  • A study in which gut microbiomes of 8,208 individuals from 2,756 families were characterized and correlated to 241 host and environmental factors defines microbiome patterns shared across diverse diseases and shows that the microbiome is shaped largely by environment and cohabitation.

    • R. Gacesa
    • A. Kurilshikov
    • R. K. Weersma
    Research
    Nature
    Volume: 604, P: 732-739
  • The structure of human cathepsin K, a potential target for treatment of osteoporosis, reveals active site differences with homologous cysteine proteinases that should enable the design of cathepsin K selective inhibitors.

    • Baoguang Zhao
    • Cheryl A. Janson
    • Sherin S. Abdel-Meguid
    Correspondence
    Nature Structural Biology
    Volume: 4, P: 109-111