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A distinct topology of BTN3A IgV and B30.2 domains controlled by juxtamembrane regions favors optimal human γδ T cell phosphoantigen sensing

γδ T cells are known to recognize phosphoantigen in the context of butyrophilins (BTN), yet the molecular rules underlying this phenomenon are unclear. Here, the authors demonstrate that a distinct topology of B30.2 and IgV domains within BTN3A complexes promotes antigen sensing and that the juxtamembrane region controls BTN complex formation.

Mohindar M. Karunakaran
Hariharan Subramanian
Thomas Herrmann
ResearchOpen Access22 Nov 2023
Nature Communications

Volume: 14, P: 1-16
Evolutionary characterization of lung adenocarcinoma morphology in TRACERx

Analyses of the TRACERx study unveil the relationship between tissue morphology, the underlying evolutionary genomic landscape, and clinical and anatomical relapse risk of lung adenocarcinomas.

Takahiro Karasaki
David A. Moore
Mariam Jamal-Hanjani
Research12 Apr 2023
Nature Medicine

Volume: 29, P: 833-845
Lung adenocarcinoma promotion by air pollutants

Combination of epidemiology, preclinical models and ultradeep DNA profiling of clinical cohorts unpicks the inflammatory mechanism by which air pollution promotes lung cancer

William Hill
Emilia L. Lim
Charles Swanton
Research05 Apr 2023
Nature

Volume: 616, P: 159-167
The human Vδ2⁺ T-cell compartment comprises distinct innate-like Vγ9⁺ and adaptive Vγ9^- subsets

Human Vδ2⁺ γδ T cells are thought to be an innate-like T-cell population. Here the authors show the Vδ2⁺ compartment contains both innate-like Vγ9⁺ and an adaptive Vγ9^- subset that undergoes clonal expansion during viral infection and can infiltrate liver tissue.

Martin S. Davey
Carrie R. Willcox
Benjamin E. Willcox
ResearchOpen Access02 May 2018
Nature Communications

Volume: 9, P: 1-14
Resolving the mystery of pyrophosphate antigen presentation

Small phosphorylated prenyl metabolites are potent activators of γδ T cells in human peripheral blood, but the molecular mechanism underlying their antigenic potency has remained a mystery. New data identify BTN3A1 as a novel antigen-presentation molecule for both microbial and host-derived phosphorylated antigens.

Carrie R Willcox
Fiyaz Mohammed
Benjamin E Willcox
News & Views20 Aug 2013
Nature Immunology

Volume: 14, P: 886-887
Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

γδ T cells are generally considered innate‐like lymphocytes. Here the authors sequence human γδ T cell receptors (TCR) to show focusing of the private Vδ1 TCR repertoire, suggesting that, unlike Vδ2 T cells, the Vδ1 T cell compartment has adaptive attributes.

Martin S. Davey
Carrie R. Willcox
Benjamin E. Willcox
ResearchOpen Access01 Mar 2017
Nature Communications

Volume: 8, P: 1-15
Genomic–transcriptomic evolution in lung cancer and metastasis

Computational and machine-learning approaches that integrate genomic and transcriptomic variation from paired primary and metastatic non-small cell lung cancer samples from the TRACERx cohort reveal the role of transcriptional events in tumour evolution.

Carlos Martínez-Ruiz
James R. M. Black
Nicholas McGranahan
ResearchOpen Access12 Apr 2023
Nature

Volume: 616, P: 543-552
Body composition and lung cancer-associated cachexia in TRACERx

Results of the TRACERx study shed new light into the association between body composition and body weight with survival in individuals with non-small cell lung cancer, and delineate potential biological processes and mediators contributing to the development of cancer-associated cachexia.

Othman Al-Sawaf
Jakob Weiss
Charles Swanton
Research12 Apr 2023
Nature Medicine

Volume: 29, P: 846-858
The evolution of lung cancer and impact of subclonal selection in TRACERx

Analyses of multiregional tumour samples from 421 patients with non-small cell lung cancer prospectively enrolled to the TRACERx study reveal determinants of tumour evolution and relationships between intratumour heterogeneity and clinical outcome.

Alexander M. Frankell
Michelle Dietzen
Charles Swanton
ResearchOpen Access12 Apr 2023
Nature

Volume: 616, P: 525-533
Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA

Measurements of subclonal expansion of ctDNA in the plasma before surgery may enable the prediction of future metastatic subclones, offering the possibility for early intervention in patients with non-small-cell lung cancer.

Christopher Abbosh
Alexander M. Frankell
Charles Swanton
Research13 Apr 2023
Nature

Volume: 616, P: 553-562
Antibodies against endogenous retroviruses promote lung cancer immunotherapy

In lung adenocarcinoma, antibodies against endogenous retroviruses promote anti-tumour activity, and expression of endogenous retroviruses can predict outcomes of immunotherapy.

Kevin W. Ng
Jesse Boumelha
George Kassiotis
ResearchOpen Access12 Apr 2023
Nature

Volume: 616, P: 563-573
The evolution of non-small cell lung cancer metastases in TRACERx

A longitudinal evolutionary analysis of 126 lung cancer patients with metastatic disease reveals the timing of metastatic divergence, modes of dissemination and the genomic events subject to selection during the metastatic transition.

Maise Al Bakir
Ariana Huebner
Charles Swanton
ResearchOpen Access12 Apr 2023
Nature

Volume: 616, P: 534-542
A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer

Wu et al. utilize multiparametric analysis of early-stage human NSCLC to characterize a population of Vδ1 T cells displaying a resident memory and effector memory phenotype, which were associated with ongoing remission.

Yin Wu
Dhruva Biswas
Charles Swanton
ResearchOpen Access30 May 2022
Nature Cancer

Volume: 3, P: 696-709
Using DNA sequencing data to quantify T cell fraction and therapy response

A robust, cost-effective technique based on whole-exome sequencing data can be used to characterize immune infiltrates, relate the extent of these infiltrates to somatic changes in tumours, and enables prediction of tumour responses to immune checkpoint inhibition therapy.

Robert Bentham
Kevin Litchfield
Nicholas McGranahan
Research08 Sept 2021
Nature

Volume: 597, P: 555-560
Molecular mapping of QTLs for yield related traits in recombinant inbred line (RIL) population derived from the popular rice hybrid KRH-2 and their validation through SNP genotyping

Swapnil Ravindra Kulkarni
S. M. Balachandran
R. M. Sundaram
ResearchOpen Access13 Aug 2020
Scientific Reports

Volume: 10, P: 1-21
Grain Fe and Zn content, heterosis, combining ability and its association with grain yield in irrigated and aerobic rice

G. Anusha
D. Sanjeeva Rao
P. Senguttuvel
ResearchOpen Access19 May 2021
Scientific Reports

Volume: 11, P: 1-12
Author Correction: The evolution of lung cancer and impact of subclonal selection in TRACERx

Alexander M. Frankell
Michelle Dietzen
Charles Swanton
Amendments and CorrectionsOpen Access04 Jul 2024
Nature

Volume: 631, P: E15

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