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Showing 1–50 of 83 results

Advanced filters: Author: R. M. Pommier Clear advanced filters

p21^CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine

T Furuta
R L Hayward
Y Pommier
Research16 Jan 2006
Oncogene

Volume: 25, P: 2839-2849
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

Donald W. Nicholson
Ambereen Ali
Douglas K. Miller
Research06 Jul 1995
Nature

Volume: 376, P: 37-43
Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis

N Droin
L Dubrez
E Solary
Research09 Jun 1998
Oncogene

Volume: 16, P: 2885-2894
Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer

A multi-modal analysis of pre-metastatic liver biopsies from patients with localized pancreatic cancer with a minimum of 3 years of follow-up shows that immunological, proliferative and metabolomic features distinguish patients who develop metastases from disease-free survivors and can be used to predict outcomes.

Linda Bojmar
Constantinos P. Zambirinis
David Lyden
Research28 Jun 2024
Nature Medicine

Volume: 30, P: 2170-2180
Sensitivity to CPT-11 of xenografted human colorectal cancers as a function of microsatellite instability and p53 status

R A Bras-Gonçalves
C Rosty
M-F Poupon
ResearchOpen Access20 Jan 2000
British Journal of Cancer

Volume: 82, P: 913-923
Reversal of MDR1-associated resistance to topotecan by PAK-200S, a new dihydropyridine analogue, in human cancer cell lines

U Vanhoefer
M R Müller
A Harstrick
ResearchOpen Access26 Nov 1999
British Journal of Cancer

Volume: 81, P: 1304-1310
CHEK2 genomic and proteomic analyses reveal genetic inactivation or endogenous activation across the 60 cell lines of the US National Cancer Institute

G Zoppoli
S Solier
Y Pommier
Research18 Jul 2011
Oncogene

Volume: 31, P: 403-418
Trinucleotide repeat length instability and age of onset in Huntington's disease

M. Duyao
C. Ambrose
M. MacDonald
Research01 Aug 1993
Nature Genetics

Volume: 4, P: 387-392
Integrated epigenetic and genetic programming of primary human T cells

Multiplexed editing in primary human T cells generates enhanced immune cell therapies.

Laine Goudy
Alvin Ha
Luke A. Gilbert
ResearchOpen Access21 Oct 2025
Nature Biotechnology

P: 1-12
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

Arkady Celeste
Oscar Fernandez-Capetillo
André Nussenzweig
Research09 Jun 2003
Nature Cell Biology

Volume: 5, P: 675-679
Doxorubicin cellular pharmacokinetics and DNA breakage in a multi-drug resistant B16 melanoma cell line

R Supino
M Mariani
G Parmiani
Research01 Feb 1988
British Journal of Cancer

Volume: 57, P: 142-146
Phase I study of sequentially administered topoisomerase I inhibitor (irinotecan) and topoisomerase II inhibitor (etoposide) for metastatic non-small-cell lung cancer

M Ando
K Eguchi
N Saijo
Research01 Dec 1997
British Journal of Cancer

Volume: 76, P: 1494-1499
Thymocyte apoptosis induced by p53-dependent and independent pathways

A. R. Clarke
C. A. Purdie
A. H. Wyllie
Research29 Apr 1993
Nature

Volume: 362, P: 849-852
Desynchronization of the oral temperature circadian rhythm and intolerance to shift work

A. Reinberg
P. Andlauer
P. Bourdeleau
Research15 Mar 1984
Nature

Volume: 308, P: 272-274
Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro

K J Bowman
D R Newell
N J Curtin
ResearchOpen Access03 Jan 2001
British Journal of Cancer

Volume: 84, P: 106-112
A phase I clinical and pharmacokinetic study of the new topoisomerase inhibitor GI147211 given as a 72-h continuous infusion

L Paz-Ares
R Kunka
P O'Dwyer
Research01 Nov 1998
British Journal of Cancer

Volume: 78, P: 1329-1336
BRCA1 as a potential human prostate tumor suppressor: modulation of proliferation, damage responses and expression of cell regulatory proteins

Saijun Fan
Ji-An Wang
Eliot M Rosen
Research16 Jun 1998
Oncogene

Volume: 16, P: 3069-3082
Cytotoxic therapy with etoposide and cisplatin in advanced adrenocortical carcinoma

R Bonacci
A Gigliotti
M Schlumberger
Research01 Aug 1998
British Journal of Cancer

Volume: 78, P: 546-549
Schedule-dependent cytotoxicity of SN-38 in p53 wild-type and mutant colon adenocarcinoma cell lines

R H te Poele
S P Joel
ResearchOpen Access26 Nov 1999
British Journal of Cancer

Volume: 81, P: 1285-1293
Genomic and evolutionary classification of lung cancer in never smokers

Whole-genome sequencing of lung cancer in never smokers identifies different copy number subtypes and shows a lack of tobacco smoking signatures, even in cases exposed to secondhand smoke.

Tongwu Zhang
Philippe Joubert
Maria Teresa Landi
Research06 Sept 2021
Nature Genetics

Volume: 53, P: 1348-1359
Needle-like structures discovered on positively charged lightning branches

Radio interferometric observations of lightning over the Netherlands reveal small needle-shaped plasma structures associated with the positive leader channels, explaining why cloud-to-ground lightning connects to the ground multiple times.

B. M. Hare
O. Scholten
P. Zucca
Research17 Apr 2019
Nature

Volume: 568, P: 360-363
Mdr1/P-glycoprotein, topoisomerase, and glutathione-S-transferase π gene expression in primary and relapsed state adult and childhood leukaemias

V Gekeler
G Frese
D Niethammer
Research01 Sept 1992
British Journal of Cancer

Volume: 66, P: 507-517
Calmodulin inhibitor trifluoperazine in combination with doxorubicin induces the selection of tumour cells with the multidrug resistant phenotype

N Kamath
D Grabowski
R Ganapathi
Research01 Jun 1993
British Journal of Cancer

Volume: 67, P: 1203-1208
Bcl-2 expression in rituximab refractory cutaneous B-cell lymphoma

M Wobser
H Voigt
J C Becker
ResearchOpen Access01 May 2007
British Journal of Cancer

Volume: 96, P: 1540-1543
Ubiquitous atmospheric production of organic acids mediated by cloud droplets

The oxidation of hydrated formaldehyde from cloud droplets is the dominant source of atmospheric formic acid, increasing atmospheric acidity by reducing cloud and rainwater pH.

B. Franco
T. Blumenstock
D. Taraborrelli
ResearchOpen Access12 May 2021
Nature

Volume: 593, P: 233-237
Successful local regional therapy with topotecan of intraperitoneally growing human ovarian carcinoma xenografts

G Pratesi
M Tortoreto
F Zunino
Research01 Mar 1995
British Journal of Cancer

Volume: 71, P: 525-528
Correction: Corrigendum: A large light-mass component of cosmic rays at 10¹⁷–10^17.5 electronvolts from radio observations

S. Buitink
A. Corstanje
J. A. Zensus
Amendments and Corrections20 Jul 2016
Nature

Volume: 537, P: 572
A phase I clinical trial of continual alternating etoposide and topotecan in refractory solid tumours

R T Penson
M V Seiden
J P Eder Jr
ResearchOpen Access28 Jun 2005
British Journal of Cancer

Volume: 93, P: 54-59
A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress

Whereas cisplatin and carboplatin kill cancer cells by inducing DNA damage, another platinum derivative, oxaliplatin, induces cell death by triggering ribosome biogenesis stress.

Peter M Bruno
Yunpeng Liu
Michael T Hemann
Research27 Feb 2017
Nature Medicine

Volume: 23, P: 461-471
Induction of breast cancer resistance protein by the camptothecin derivative DX-8951f is associated with minor reduction of antitumour activity

A H van Hattum
I J Hoogsteen
E Boven
ResearchOpen Access03 Sept 2002
British Journal of Cancer

Volume: 87, P: 665-672
Involvement of basic fibroblast growth factor in suramin-induced inhibition of V79/AP4 fibroblast cell proliferation

N Bernardini
F Giannessi
M Del Tacca
Research01 Jun 1993
British Journal of Cancer

Volume: 67, P: 1209-1216
Marked long-term decline in ambient CO mixing ratio in SE England, 1997–2014: evidence of policy success in improving air quality

D. Lowry
M. E. Lanoisellé
E. G. Nisbet
ResearchOpen Access23 May 2016
Scientific Reports

Volume: 6, P: 1-12
The multidrug resistance phenotype

SB Kaye
Editorial01 Dec 1988
British Journal of Cancer

Volume: 58, P: 691-694
CPT-11 converting carboxylesterase and topoisomerase I activities in tumour and normal colon and liver tissues

S Guichard
C Terret
P Canal
ResearchOpen Access09 Apr 1999
British Journal of Cancer

Volume: 80, P: 364-370
Therapy in old patients with isolated systolic hypertension: fourth progress report on the Syst-Eur trial

R Antikainen
J Tuomilehto
JA Staessen
Research01 May 1997
Journal of Human Hypertension

Volume: 11, P: 263-269
Infiltration of mononuclear inflammatory cells into primary colorectal carcinomas: an immunohistological analysis

L Håkansson
G Adell
R Sjödahl
Research01 Feb 1997
British Journal of Cancer

Volume: 75, P: 374-380
A large light-mass component of cosmic rays at 10¹⁷–10^17.5 electronvolts from radio observations

High-resolution radio measurements of air showers—cascades of secondary particles in the atmosphere initiated by cosmic rays—reveal that cosmic rays with energies of 10¹⁷–10^17.5 electronvolts have a mixed composition, with light elements (protons and helium nuclei) making up 80 per cent of their mass.

S. Buitink
A. Corstanje
J. A. Zensus
Research02 Mar 2016
Nature

Volume: 531, P: 70-73
A prolonged methoxymorpholino doxorubicin (PNU-152243 or MMRDX) infusion schedule in patients with solid tumours: a phase 1 and pharmacokinetic study

E Fokkema
J Verweij
H J M Groen
ResearchOpen Access20 Jan 2000
British Journal of Cancer

Volume: 82, P: 767-771
Relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumors

Matthew S. Dietz
Thomas L. Sutton
Melissa H. Wong
ResearchOpen Access01 Jul 2021
Scientific Reports

Volume: 11, P: 1-13
Enhanced etoposide sensitivity following adenovirus-mediated human topoisomerase II α gene transfer is independent of topoisomerase II β

Z Zhou
L A Zwelling
E S Kleinerman
ResearchOpen Access28 Aug 2001
British Journal of Cancer

Volume: 85, P: 747-751
IGF-1, IGF-2 and IGFBP-3 in prediagnostic serum: association with colorectal cancer in a cohort of Chinese men in Shanghai

N M Probst-Hensch
J-M Yuan
M C Yu
ResearchOpen Access27 Nov 2001
British Journal of Cancer

Volume: 85, P: 1695-1699
Induction of apoptosis by taxol and cisplatin and effect on cell cycle-related proteins in cisplatin-sensitive and -resistant human ovarian cells

N Zaffaroni
R Silvestrini
R Villa
Research01 May 1998
British Journal of Cancer

Volume: 77, P: 1378-1385
Pathway from subducting slab to surface for melt and fluids beneath Mount Rainier

Magnetotelluric data from the state of Washington, USA, are used to image the fluid–melt phase of volcanic subduction in Mt Rainier, revealing fluid release at or near the top of the slab, and its migration into the overlying mantle.

R. Shane McGary
Rob L. Evans
Stéphane Rondenay
Research16 Jul 2014
Nature

Volume: 511, P: 338-340
A Novel Aspochalasin with HIV-1 Integrase Inhibitory Activity from Aspergillus flavipes

Simone Rochfort
Joanne Ford
David Rhodes
Research01 Apr 2005
The Journal of Antibiotics

Volume: 58, P: 279-283
Carboplatin plus paclitaxel in extensive small cell lung cancer: a multicentre phase 2 study

C Gridelli
L Manzione
C Gallo
ResearchOpen Access03 Jan 2001
British Journal of Cancer

Volume: 84, P: 38-41
Defective induction but normal activation and function of p53 in mouse cells lacking poly-ADP-ribose polymerase

Munna L Agarwal
Archana Agarwal
George R Stark
Research28 Aug 1997
Oncogene

Volume: 15, P: 1035-1041
Is increased time to diagnosis and treatment in symptomatic cancer associated with poorer outcomes? Systematic review

R D Neal
P Tharmanathan
J Emery
ResearchOpen Access03 Mar 2015
British Journal of Cancer

Volume: 112, P: S92-S107
Increased sensitivity to platinum drugs of cancer cells with acquired resistance to trabectedin

B Colmegna
S Uboldi
M D'Incalci
ResearchOpen Access03 Dec 2015
British Journal of Cancer

Volume: 113, P: 1687-1693
Cellular and molecular signal transduction pathways modulated by rituximab (rituxan, anti-CD20 mAb) in non-Hodgkin's lymphoma: implications in chemosensitization and therapeutic intervention

Ali R Jazirehi
Benjamin Bonavida
Reviews24 Mar 2005
Oncogene

Volume: 24, P: 2121-2143
Additive interaction of gefitinib (‘Iressa’, ZD1839) and ionising radiation in human tumour cells in vitro

N Giocanti
C Hennequin
V Favaudon
ResearchOpen Access16 Nov 2004
British Journal of Cancer

Volume: 91, P: 2026-2033

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