Hydrogen bond pairing and supramolecular synthon approaches have influenced the understanding of cocrystal formation for decades, but whether or not hydrogen bonds are the dominant interaction in cocrystals has not been extensively studied. Here, the authors perform an extensive analysis of 1:1 two-component cocrystals in the Cambridge Structural Database and reveal that when interaction strength and frequency are combined, hydrogen bonds and stacking/T-type interactions contribute equally to the stabilisation of cocrystal lattices.
- Aurora J. Cruz-Cabeza
- Peter R. Spackman
- Amy V. Hall
