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A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein

A redesigned antiviral miniprotein based on a dimeric helix-hairpin motif binds and dimerizes the RBD of the SARS-CoV-2 spike protein and inhibits viral infection by inhibiting spike interaction with ACE2.

Bhavesh Khatri
Ishika Pramanick
Jayanta Chatterjee
ResearchOpen Access02 Jun 2022
Nature Chemical Biology

Volume: 18, P: 1046-1055

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A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein

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