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Quantum spin ice is a magnetic state of matter which can play host to monopole excitations. Using polarized neutron scattering, Changet al. show that the quantum spin ice material ytterbium titanate undergoes a Higgs transition of emergent magnetic monopoles from a Coulomb liquid to a ferromagnetic phase.

Eighty-nine percent of the Trypanosoma brucei proteome is mapped using fluorescence microscopy and cell lines expressing endogenously tagged proteins, and presented in a resource for the community named TrypTag.org.

By assembling the genomes of 22 Fraxinus species and conducting comparisons including further species, the authors identify candidate loci for emerald ash borer resistance that have evolved convergently.

This Registered Report presents evidence from 87 countries and regions showing that brief emotion-regulation interventions consistently reduced negative emotions and increased positive emotions during the COVID-19 pandemic.

Peter Donnelly and colleagues report a genome-wide association study for Barrett's esophagus, a common premalignant condition associated with stomach acid reflux and predisposing to esophageal adenocarcinoma. They identify two loci associated with susceptibility to Barrett's esophagus.

Photoactive and semiconducting metal-organic frameworks are desirable for electrical and photoelectrical devices, but remain rare. Here Demets and co-workers design a naphthalene diimide and cobalt based MOF with anisotropic electrical semiconductivity and a high responsivity of 2.5 × 10⁵ A W⁻¹.

A comparison of RNA-seq and microarray data from samples treated with diverse drugs highlights a dependency of cross-platform concordance on treatment effect.

A primordial carbon-to-oxygen ratio (C/O) greater than 0.8 in an exoplanet causes a carbide-dominated interior, as opposed to the silicate-dominated composition found on Earth; the atmospheres also can differ from those in the Solar System. The solar C/O is 0.54. This study reports an analysis of spectra from the transiting hot Jupiter WASP-12b that reveals that C/O>1 in its atmosphere, based upon the observed concentrations of the prominent molecules CO, CH₄ and H₂O.

Ron Wevers and colleagues report that mutations in the methanethiol oxidase gene SELENBP1 cause chronic extraoral halitosis. They find that enzyme deficiency leads to increased levels of methanethiol and dimethylsulfide in the breath and that knockout mice have similar biochemical phenotypes.

The canonical auxin receptor complex mediates gene expression, but it is also necessary for responses far too rapid to be mediated by transcription. An innovative setup that uses advanced microscopy and microfluidics can record auxin-induced changes within 30 seconds during root growth.

A large meta-analysis combining genome-wide and custom high-density genotyping array data identifies 63 new susceptibility loci for prostate cancer, enhancing fine-mapping efforts and providing insights into the underlying biology.

The marine bacterium Puniceibacterium antarcticum SM1211 can produce acrylate from dimethylsulfoniopropionate (DMSP) cleavage by the DMSP lyase, DddL, which protects against grazing by a ciliate predator.

Domain structures influence significantly the properties of ferroelectric materials. Here, the authors use phase-field simulations to show that spatially homogeneous defect charges in BiFeO₃ may play a key role in the formation of the experimentally observed enigmatic zigzag domain structures, providing insights into pyramidal-domain formation in perovskite oxides.

LTT 9779 b is Neptune-sized planet rotating around its star with a period of 0.79 days and an equilibrium temperature of 2,000 K. It is not clear how it retained its atmospheric envelope, which contains ~10% of H/He, as it should have been photoevaporated by now.

The genome sequence and genetic diversity of European ash (Fraxinus excelsior) trees reveals the species’ varying susceptibility to ash dieback.

Auxin is perceived by a co-receptor complex that contains a TIR1 F-box protein and an Aux/IAA transcriptional repressor. The combinatorial diversity of auxin co-receptor complexes and their distinct spectra of affinities offer a means to tune plant cell sensitivity to a wide range of auxin concentrations.

Phytophthora infestans is a fungus-like eukaryote and the most destructive pathogen of potato, with current annual worldwide potato crop losses due to late blight estimated at $6.7 billion. Here, the sequence of the P. infestans genome is reported. Comparison with two other Phytophthora genomes showed rapid turnover and extensive expansion of certain secreted disease effector proteins, probably explaining the rapid adaptability of the pathogen to host plants.

Crowdsourcing analysis improves computational prediction of cytotoxic responses in humans.

Rosalind Eeles and colleagues report meta-analysis of genome-wide association studies for prostate cancer and genotyping on the custom iCOGS array in 25,074 cases and 24,272 controls from 32 studies available in the PRACTICAL Consortium. They identify 23 new prostate cancer susceptibility loci, 20 of which are associated with both aggressive and non-aggressive disease.

Rosalind Eeles, Christopher Haiman and colleagues report genome-wide association and meta-analyses of prostate cancer in populations of European, African, Japanese and Latino ancestry. They identify 23 new susceptibility loci, including one associated with early-onset prostate cancer.

To guide the safe implementation of the next generation of surgical robots, the IDEAL Robotics Colloquium provides recommendations for their evaluation throughout the product life cycle—considering multiple perspectives within and beyond the surgical team.

Clare Turnbull and colleagues report discovery of 19 new susceptibility loci for testicular germ cell tumor (TGCT) and provide evidence for a network of physical interactions between TGCT risk variants and candidate causal genes. Their findings implicate widespread disruption of developmental transcriptional regulators in TGCT susceptibility, consistent with failed primordial germ cell differentiation as an initiating step in oncogenesis.

The astronomical event GW170817, detected in gravitational and electromagnetic waves, is used to determine the expansion rate of the Universe, which is consistent with and independent of existing measurements.

Paul Thompson and colleagues report a genome-wide association study for hippocampal, intracranial and total brain volume. They identify a locus at 12q24 associated with hippocampal volume and a locus at 12q14 associated with intracranial volume.

Multiregion spatial histology, exome and transcriptome data from patients with non-small cell lung cancer suggest that cancer subclones from immune cold regions diversify later than subclones from immune hot regions

Studies of psychiatric disorders have traditionally focused on emotional symptoms, such as depression, anxiety and hallucinations, but poorly controlled cognitive deficits are also prominent and severely compromise quality of life. This article critically discusses our understanding of the nature and causes of cognitive impairment in psychiatric disorders, and reviews the opportunities and challenges in improving cognition in patients, including the development of more effective translational research approaches.

High-resolution X-ray spectra reveal highly ionized X-ray gas flows in a nearby tidal disruption event, ASASSN-14li, near to the black hole of the galaxy PGC 043234.

The CONSORT-AI and SPIRIT-AI extensions improve the transparency of clinical trial design and trial protocol reporting for artificial intelligence interventions.