Molecular imprinting of methylene blue (MB), a small cationic dye, was conducted to free-standing films prepared from polyion complexes of chondroitin sulfate and chitosan. Molecular permeability of the MB-imprinted films in phosphate-buffered saline (PBS) was evaluated. MB, orange II and porphyrin derivatives were used as permeants to clarify the effects of charge and size of the permeant on the permeation behaviors. In the case of porphyrin derivatives, the inner voids of the films were not significant for the permeation behavior, but the surface charges of the films were important.
- Takuya Sagawa
- Masaya Oishi
- Mineo Hashizume
